Milana Frenkel-Morgenstern | Liquid Biopsy | Women Researcher Award

Dr. Milana Frenkel-Morgenstern | Liquid Biopsy | Women Researcher Award

Dr. Milana Frenkel-Morgenstern is an Israeli scientist and Principal Investigator at the Scojen Institute of Synthetic Biology, Reichman University. She specializes in bioinformatics, systems biology, and synthetic biology. With a rich background spanning molecular genetics, computer science, and structural biology, she has held key positions in institutions such as Bar-Ilan University, Weizmann Institute of Science, and the Spanish National Research Centre. She is renowned for her pioneering work in liquid biopsies, chimeric RNAs, and non-invasive diagnostic tools. Dr. Frenkel-Morgenstern has published extensively, served on prestigious evaluation panels, and received numerous fellowships and awards, including the Miguel Servet Fellowship and the Rector Prize for Scientific Innovation. Her leadership in both academic and public scientific communities, combined with a strong record of mentorship and university service, highlights her influential presence in biomedical research. She is also the founder of the “Art in Science” session at ISMB, reflecting her commitment to interdisciplinary innovation.

Profile

🎓 Education

Dr. Frenkel-Morgenstern earned her PhD in Molecular Genetics at the Weizmann Institute of Science under Prof. Shmuel Pietrokovski, specializing in bioinformatics and systems biology. Prior to that, she completed her MSc in Mathematics and Computer Science with a thesis in molecular biology from Bar-Ilan University, mentored by Prof. Ron Unger and Prof. Amihood Amir. Her undergraduate studies were also at Bar-Ilan University, where she earned a BSc in Mathematics and Computer Science. Her multidisciplinary education seamlessly blends life sciences, computational modeling, and mathematical analysis, forming the foundation for her later innovations in biomedical research. This strong computational background, coupled with a deep understanding of molecular biology, positioned her to excel in complex systems analysis, machine learning, and genomics, leading to a distinguished academic and research career. Her training has enabled her to lead translational biomedical projects, particularly in the fields of cancer research, structural bioinformatics, and synthetic biology.

🧪 Experience

Dr. Milana Frenkel-Morgenstern has over two decades of academic and research experience. She is currently Principal Investigator and Senior Lecturer at Reichman University. Prior to this, she was a senior faculty member at Bar-Ilan University’s Azrieli Faculty of Medicine for a decade. Internationally, she served as a staff scientist at the Spanish National Cancer Research Centre (CNIO) and was a postdoctoral fellow in the labs of Prof. Alfonso Valencia and Prof. Uri Alon. She has also been a scientific advisor and educator at the Weizmann Institute’s Davidson Institute. Dr. Frenkel-Morgenstern has taught a range of graduate-level courses in genomics, bioinformatics, and computational biology. She has been deeply involved in institutional governance, serving on data science boards, senate committees, and multiple departmental leadership roles. Her professional journey reflects a blend of research excellence, teaching dedication, and scientific outreach, including organizing the “Art in Science” initiative for ISMB/ECCB.

🏅 Awards and Honors

Dr. Frenkel-Morgenstern has received numerous prestigious awards recognizing her research and innovation. She was awarded the Rector Prize for Scientific Innovation by Bar-Ilan University in 2021, and the Bioinfo4Women Fellowship by the Barcelona Supercomputing Center from 2016–2019. Her work on RNA sequencing earned her the Miguel Servet Fellowship (2011–2015), and she received international postdoctoral fellowships from Caja Navarra Foundation and Horvitz Foundation. Her academic contributions have been recognized through several Travel Awards from ISMB, ECCB, and RECOMB, and she earned Outstanding Poster Awards in international conferences. As a guest editor for leading journals and evaluator for major funding bodies (ERC, ISF, GIF, etc.), her influence extends beyond research to shaping the global scientific agenda. She also received the Excellent Lecturer Award (2017) at Bar-Ilan University and serves as an academic reviewer and thesis evaluator for institutions across Israel, Europe, and Asia, demonstrating global academic leadership.

🔬 Research Focus

Dr. Frenkel-Morgenstern’s research centers on liquid biopsy technologies, cell-free nucleic acids (cfDNA/cfRNA), and systems and synthetic biology. Her lab investigates molecular biomarkers for cancer, arthritis, and prenatal diagnostics, developing computational platforms that utilize next-generation sequencing, AI, and machine learning. She explores chimeric RNAs, chromosomal translocations, and non-optimal codon usage, linking genetic regulation with disease mechanisms. Her interdisciplinary work bridges microbiome analysis, metagenomics, genome profiling, and protein-protein interaction networks, with translational applications in personalized medicine. In addition, she applies big data analytics to understand the cell cycle, identify druggable targets, and improve early diagnostics using non-invasive methods. Dr. Frenkel-Morgenstern is also investigating novel areas such as the relationship between melanin, Vitamin D, and mRNA technologies, relevant to both clinical and cosmetic science. Her research is both hypothesis-driven and data-intensive, aiming to convert large-scale biological data into practical medical insights and biotechnology solutions with significant societal impact.

Conclusion

Dr. Milana Frenkel-Morgenstern is a leading scientist in bioinformatics and synthetic biology whose interdisciplinary research in liquid biopsies, systems biology, and AI-driven genomics continues to impact cancer diagnostics and translational medicine globally.

Publications
  • Applications for Circulating Cell-Free DNA in Oral Squamous Cell Carcinoma: A Non-Invasive Approach for Detecting Structural Variants, Fusions, and Oncoviruses

    Cancers
    2025-06 | Journal article | Author
    CONTRIBUTORS: Mahua Bhattacharya; Dan Yaniv; Dylan P. D’Souza; Eyal Yosefof; sharon tzelnick; Rajesh Detroja; Tal Wax; Adva Levy-Barda; Gideon Baum; Aviram Mizrachi et al.
  • ChiTaRS 8.0: the comprehensive database of chimeric transcripts and RNA-seq data with applications in liquid biopsy

    Nucleic Acids Research
    2025-01-06 | Journal article
    CONTRIBUTORS: Dylan DSouza; Lihi Bik; Olawumi Giwa; Shahaf Cohen; Hilit Levy Barazany; Tali Siegal; Milana Frenkel-Morgenstern
  • The applications of circulating cell-free DNA for oral squamous cell carcinoma patients as non-invasive diagnostics of structural variants, fusions and oncoviruses

    2023-11-30 | Preprint
    CONTRIBUTORS: Mahua Bhattacharya; Dan Yaniv; Eyal Yosefof; Sharon Tzelnick; Rajesh Detroja; Dylan P. D’Souza; Gidi Baum; Aviram Mizrachi; Gideon Bachar; Milana Frenkel Morgenster

Natalia Baran | Cancer Research | Best Researcher Award

Assist. Prof. Dr. Natalia Baran | Cancer Research | Best Researcher Award

Leading Attending at InselSpital Bern, Switzerland.

Dr. Natalia Baran is an Assistant Professor in the Department of Leukemia at MD Anderson Cancer Center, where she focuses on developing novel therapeutic strategies targeting metabolic vulnerabilities in leukemia. Her expertise lies in understanding how metabolic reprogramming can lead to drug resistance and contribute to leukemia progression. With a medical background and extensive experience in both clinical and research settings, Dr. Baran has been at the forefront of studies that aim to modulate metabolic pathways to enhance anti-leukemic responses. By combining insights from molecular biology, immunology, and clinical practice, she is actively working toward discovering innovative treatments for leukemia. Dr. Baran’s research holds great promise in advancing leukemia therapy, particularly by targeting metabolic reprogramming in the context of therapy resistance. Her multidisciplinary approach, integrating clinical data with laboratory research, makes her a key figure in leukemia research.

Profile

Scopus

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Orcid

Education:

Dr. Natalia Baran completed her undergraduate studies in Biotechnology, earning a Master of Science degree in 2006 from Wroclaw University of Science and Technology in Poland. She further pursued medical education and obtained her Medical Doctor (MD) degree from Wroclaw Medical University in 2007. Driven by her passion for research, Dr. Baran earned a Ph.D. in Medicine from the University of Bonn in 2015. Her doctoral research laid the foundation for her current focus on leukemia and metabolic reprogramming. In addition, Dr. Baran underwent extensive postdoctoral training at MD Anderson Cancer Center, where she honed her expertise in hematology and oncology, contributing significantly to translational research in leukemia. Her diverse educational background, blending science and medicine, has shaped her comprehensive approach to cancer research.

Professional Experience:

Dr. Baran has a rich professional experience that bridges clinical practice and cutting-edge research. After completing her MD, she pursued clinical residencies in Internal Medicine, Hematology, and Oncology at prestigious German institutions, including the University of Heidelberg and the University of Bonn. This clinical experience laid the groundwork for her subsequent focus on leukemia research. In 2016, she joined MD Anderson Cancer Center as a Postdoctoral Fellow in the Department of Leukemia. During her postdoctoral tenure, Dr. Baran worked closely with Dr. Marina Konopleva, exploring the role of metabolic pathways in leukemia resistance. By 2022, she had transitioned to an Assistant Professor role, continuing her translational research in leukemia, with a particular emphasis on identifying novel therapeutic strategies. Her clinical and research experiences synergize to enhance her contributions to the leukemia research community.

Research Interests:

Dr. Baran’s research is primarily centered on exploring metabolic vulnerabilities and their role in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Her work seeks to understand the mechanisms through which metabolic reprogramming in leukemia cells contributes to drug resistance and tumor progression. Dr. Baran is particularly interested in how modulating the metabolic environment can enhance the effectiveness of leukemia therapies. By focusing on the interplay between metabolism and leukemic cell survival, she aims to identify new therapeutic strategies that target metabolic pathways to overcome resistance to traditional treatments. Her research also explores how immune modulation can be integrated with metabolic interventions to develop more efficient leukemia therapies.

Awards and Honors:

Dr. Baran has received recognition for her contributions to leukemia research, although specific awards are not detailed in available sources. However, her research has been featured prominently in major scientific forums, including the Annual Metabolism in Cancer Symposium organized by MD Anderson. Her work has earned her respect within the scientific community, as evidenced by her continued role as an Assistant Professor and her involvement in prestigious cancer research initiatives. Dr. Baran’s impact is evident in her ongoing efforts to bridge the gap between basic science and clinical application, aiming to revolutionize leukemia treatment.

Skills:

Dr. Baran’s research skills encompass a wide range of techniques in molecular biology, cell culture, and metabolic analysis. She is highly proficient in studying the metabolic pathways that drive leukemia, using state-of-the-art technologies such as high-resolution metabolic flux analysis, RNA sequencing, and advanced cell imaging. Dr. Baran is skilled at integrating basic science with clinical data, ensuring that her research translates into practical therapeutic interventions. Her expertise in immunology further complements her research in leukemia, allowing her to investigate the potential of combining metabolic therapies with immune modulation to improve patient outcomes. Her interdisciplinary approach is a key strength in her ongoing work in leukemia research.

Publication Top Notes

A Selective BCL-XL PROTAC Degrader Achieves Safe and Potent Antitumor Activity

  • Authors: S Khan, X Zhang, D Lv, Q Zhang, Y He, P Zhang, X Liu, D Thummuri, et al.
  • Journal: Nature Medicine
  • Volume: 25(12), Pages 1938–1947
  • Cited by: 515
  • Year: 2019

Targeting a Cytokine Checkpoint Enhances the Fitness of Armored Cord Blood CAR-NK Cells

  • Authors: M Daher, R Basar, E Gokdemir, N Baran, N Uprety, AK Nunez Cortes, et al.
  • Journal: Blood, The Journal of the American Society of Hematology
  • Volume: 137(5), Pages 624–636
  • Cited by: 226
  • Year: 2021

Inhibiting Glutaminase in Acute Myeloid Leukemia: Metabolic Dependency of Selected AML Subtypes

  • Authors: P Matre, J Velez, R Jacamo, Y Qi, X Su, T Cai, SM Chan, A Lodi, et al.
  • Journal: Oncotarget
  • Volume: 7(48), Pages 79722
  • Cited by: 194
  • Year: 2016

Complex I Inhibitor of Oxidative Phosphorylation in Advanced Solid Tumors and Acute Myeloid Leukemia: Phase I Trials

  • Authors: TA Yap, N Daver, M Mahendra, J Zhang, C Kamiya-Matsuoka, et al.
  • Journal: Nature Medicine
  • Volume: 29(1), Pages 115–126
  • Cited by: 182
  • Year: 2023

Molecular Pathways: Hypoxia-Activated Prodrugs in Cancer Therapy

  • Authors: N Baran, M Konopleva
  • Journal: Clinical Cancer Research
  • Volume: 23(10), Pages 2382–2390
  • Cited by: 126
  • Year: 2017

Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood–Derived NK Cells Facilitates CAR-Like Responses Against CD30+ Malignancies

  • Authors: LN Kerbauy, ND Marin, M Kaplan, PP Banerjee, MM Berrien-Elliott, et al.
  • Journal: Clinical Cancer Research
  • Volume: 27(13), Pages 3744–3756
  • Cited by: 117
  • Year: 2021

Clonal Selection and Therapy Resistance in Acute Leukemias: Mathematical Modelling Explains Different Proliferation Patterns at Diagnosis and Relapse

  • Authors: T Stiehl, N Baran, AD Ho, A Marciniak-Czochra
  • Journal: Journal of The Royal Society Interface
  • Volume: 11(94), Article ID 20140079
  • Cited by: 106
  • Year: 2014

Activation of RAS/MAPK Pathway Confers MCL-1 Mediated Acquired Resistance to BCL-2 Inhibitor Venetoclax in Acute Myeloid Leukemia

  • Authors: Q Zhang, B Riley-Gillis, L Han, Y Jia, A Lodi, H Zhang, S Ganesan, R Pan, et al.
  • Journal: Signal Transduction and Targeted Therapy
  • Volume: 7(1), Article ID 51
  • Cited by: 104
  • Year: 2022

Conclusion:

Dr. Natalia Baran is a prominent researcher whose work in leukemia has the potential to transform therapeutic approaches, especially through targeting metabolic pathways. Her strong academic background, combined with extensive clinical and research experience, enables her to address one of the most pressing challenges in leukemia treatment: drug resistance. By focusing on metabolic reprogramming, Dr. Baran is paving the way for innovative strategies to combat leukemia and improve patient outcomes. Her expertise in integrating basic research with clinical applications ensures that her contributions will have a lasting impact on the field of oncology, particularly in the development of new, more effective therapies for leukemia.