Dr. Milana Frenkel-Morgenstern | Liquid Biopsy | Women Researcher Award

Dr. Milana Frenkel-Morgenstern is an Israeli scientist and Principal Investigator at the Scojen Institute of Synthetic Biology, Reichman University. She specializes in bioinformatics, systems biology, and synthetic biology. With a rich background spanning molecular genetics, computer science, and structural biology, she has held key positions in institutions such as Bar-Ilan University, Weizmann Institute of Science, and the Spanish National Research Centre. She is renowned for her pioneering work in liquid biopsies, chimeric RNAs, and non-invasive diagnostic tools. Dr. Frenkel-Morgenstern has published extensively, served on prestigious evaluation panels, and received numerous fellowships and awards, including the Miguel Servet Fellowship and the Rector Prize for Scientific Innovation. Her leadership in both academic and public scientific communities, combined with a strong record of mentorship and university service, highlights her influential presence in biomedical research. She is also the founder of the “Art in Science” session at ISMB, reflecting her commitment to interdisciplinary innovation.

Profile

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Education

Dr. Frenkel-Morgenstern earned her PhD in Molecular Genetics at the Weizmann Institute of Science under Prof. Shmuel Pietrokovski, specializing in bioinformatics and systems biology. Prior to that, she completed her MSc in Mathematics and Computer Science with a thesis in molecular biology from Bar-Ilan University, mentored by Prof. Ron Unger and Prof. Amihood Amir. Her undergraduate studies were also at Bar-Ilan University, where she earned a BSc in Mathematics and Computer Science. Her multidisciplinary education seamlessly blends life sciences, computational modeling, and mathematical analysis, forming the foundation for her later innovations in biomedical research. This strong computational background, coupled with a deep understanding of molecular biology, positioned her to excel in complex systems analysis, machine learning, and genomics, leading to a distinguished academic and research career. Her training has enabled her to lead translational biomedical projects, particularly in the fields of cancer research, structural bioinformatics, and synthetic biology.

Experience

Dr. Milana Frenkel-Morgenstern has over two decades of academic and research experience. She is currently Principal Investigator and Senior Lecturer at Reichman University. Prior to this, she was a senior faculty member at Bar-Ilan University’s Azrieli Faculty of Medicine for a decade. Internationally, she served as a staff scientist at the Spanish National Cancer Research Centre (CNIO) and was a postdoctoral fellow in the labs of Prof. Alfonso Valencia and Prof. Uri Alon. She has also been a scientific advisor and educator at the Weizmann Institute’s Davidson Institute. Dr. Frenkel-Morgenstern has taught a range of graduate-level courses in genomics, bioinformatics, and computational biology. She has been deeply involved in institutional governance, serving on data science boards, senate committees, and multiple departmental leadership roles. Her professional journey reflects a blend of research excellence, teaching dedication, and scientific outreach, including organizing the “Art in Science” initiative for ISMB/ECCB.

Awards and Honors

Dr. Frenkel-Morgenstern has received numerous prestigious awards recognizing her research and innovation. She was awarded the Rector Prize for Scientific Innovation by Bar-Ilan University in 2021, and the Bioinfo4Women Fellowship by the Barcelona Supercomputing Center from 2016–2019. Her work on RNA sequencing earned her the Miguel Servet Fellowship (2011–2015), and she received international postdoctoral fellowships from Caja Navarra Foundation and Horvitz Foundation. Her academic contributions have been recognized through several Travel Awards from ISMB, ECCB, and RECOMB, and she earned Outstanding Poster Awards in international conferences. As a guest editor for leading journals and evaluator for major funding bodies (ERC, ISF, GIF, etc.), her influence extends beyond research to shaping the global scientific agenda. She also received the Excellent Lecturer Award (2017) at Bar-Ilan University and serves as an academic reviewer and thesis evaluator for institutions across Israel, Europe, and Asia, demonstrating global academic leadership.

Research Focus

Dr. Frenkel-Morgenstern’s research centers on liquid biopsy technologies, cell-free nucleic acids (cfDNA/cfRNA), and systems and synthetic biology. Her lab investigates molecular biomarkers for cancer, arthritis, and prenatal diagnostics, developing computational platforms that utilize next-generation sequencing, AI, and machine learning. She explores chimeric RNAs, chromosomal translocations, and non-optimal codon usage, linking genetic regulation with disease mechanisms. Her interdisciplinary work bridges microbiome analysis, metagenomics, genome profiling, and protein-protein interaction networks, with translational applications in personalized medicine. In addition, she applies big data analytics to understand the cell cycle, identify druggable targets, and improve early diagnostics using non-invasive methods. Dr. Frenkel-Morgenstern is also investigating novel areas such as the relationship between melanin, Vitamin D, and mRNA technologies, relevant to both clinical and cosmetic science. Her research is both hypothesis-driven and data-intensive, aiming to convert large-scale biological data into practical medical insights and biotechnology solutions with significant societal impact.

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