Fan Zhang | Proteomics | Best Researcher Award

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Dr. Fan Zhang | Proteomics | Best Researcher Award

Fan Zhang, born on September 23, 1991, is a postdoctoral researcher specializing in cancer proteogenomics 🔬. He is currently with the Department of Pathology at Duke University 🏛️. His research leverages mass spectrometry and bioinformatics 🖥️ to investigate metabolic pathways in therapy-resistant prostate cancer and other malignancies. He has received the FY23 Prostate Cancer Research Program Early Investigator Research Award 🏆 for his work on glutamine metabolism in advanced prostate cancer. His contributions to proteogenomics have resulted in multiple high-impact publications 📄 in Nature Communications, Cell Research, and Molecular & Cellular Proteomics. Proficient in LC-MS/MS, bioinformatics analysis, and experimental techniques, his research bridges the gap between basic cancer biology and clinical applications 🏥, paving the way for novel therapeutic strategies in oncology.

Profile

Education 🎓

Fan Zhang holds a Ph.D. in Biochemistry and Molecular Biology from Fudan University (2015-2020), where he focused on proteogenomic research. He further pursued postdoctoral training in Clinical Medicine at Fudan University (2020-2022) before joining Duke University as a postdoctoral researcher in the Department of Pathology in 2023. His academic journey began with a B.S. in Applied Biological Science from Anhui Agricultural University (2011-2015). Throughout his education, he gained expertise in genomics, transcriptomics, and proteomics, developing a strong foundation in bioinformatics and experimental methodologies. His interdisciplinary training has equipped him with skills in mass spectrometry-based proteomics, omics data analysis, and cancer metabolism research. His current research at Duke University focuses on metabolic vulnerabilities in prostate cancer, aiming to develop targeted therapies. His diverse academic background enables him to integrate various scientific disciplines, contributing significantly to cancer research and precision medicine.

Experience 👨‍🏫

Fan Zhang has extensive research experience in cancer proteogenomics. Currently a postdoctoral researcher at Duke University (2023-present), he investigates metabolic vulnerabilities in prostate cancer using advanced mass spectrometry and omics analysis. Previously, he was a postdoc in Clinical Medicine at Fudan University (2020-2022), where he contributed to proteogenomic studies on various cancers, including pituitary neuroendocrine tumors and diffuse large B-cell lymphoma. His Ph.D. at Fudan University (2015-2020) focused on proteogenomic characterizations of cancer, leading to high-impact publications. He is proficient in LC-MS/MS, bioinformatics, and experimental methodologies such as Western blotting, immunofluorescence, and cell culture. His research integrates mass spectrometry with genomics and transcriptomics to uncover novel therapeutic targets. With expertise in multi-omics data analysis, he has significantly contributed to the field of cancer biology. His work is supported by prestigious grants, highlighting his role as a leading researcher in proteogenomics and precision oncology.

Research Interests 🔬

Fan Zhang’s research focuses on proteogenomics and cancer metabolism, particularly in therapy-resistant malignancies like prostate cancer, pituitary neuroendocrine tumors, and diffuse large B-cell lymphoma. He specializes in mass spectrometry-based proteomics (DDA, DIA) and integrates multi-omics approaches, including genomics, transcriptomics, and metabolomics, to uncover novel cancer vulnerabilities. His current work at Duke University investigates glutamine metabolism in castration-resistant prostate cancer, aiming to develop targeted therapies. His expertise extends to bioinformatics analysis, large-cohort omics data interpretation, and advanced LC-MS/MS techniques for various biological samples. His research has led to multiple high-impact publications, highlighting his ability to translate complex molecular data into potential clinical applications. By combining experimental and computational approaches, he aims to identify biomarkers and therapeutic targets that can improve cancer treatment. His contributions to proteogenomics play a crucial role in advancing precision oncology and understanding the metabolic reprogramming of aggressive cancers.

 

Awards & Recognitions 🏅

Fan Zhang has received multiple awards and recognitions for his contributions to cancer proteogenomics. He was awarded the Fiscal Year 2023 (FY23) Prostate Cancer Research Program (PCRP) Early Investigator Research Award (2023-2025) for his project on targeting glutamine metabolism in advanced prostate cancer (Award Number HT9425-24-1-0237). His research has been recognized through multiple first-author and co-first-author publications in high-impact journals such as Nature Communications, Molecular & Cellular Proteomics, Cell Research, and The Prostate. His work has also been featured as a cover article in Cell Research (2022). His expertise in mass spectrometry, proteogenomics, and bioinformatics has positioned him as a leading young investigator in the field. In addition to research grants, he has received accolades for his innovative contributions to metabolic studies in oncology. His commitment to advancing cancer research has been instrumental in developing novel therapeutic strategies for therapy-resistant malignancies.

Publications 📚

Kawthar Diab | Biology and Life Science | Best Researcher Award

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Prof Dr. Kawthar Diab | Biology and Life Science | Best Researcher Award

 

Profile

Education

She holds a Ph.D. in Zoology from Ain Shams University, awarded in March 2009, with her research focusing on the protective role of medicinal plants against the genotoxic effects induced by hydrocortisone in mice. Prior to that, she earned an M.Sc. in Experimental Zoology from Zagazig University in May 2003, where she conducted cytogenetic and immunogenetic studies on cisplatin and 5-fluorouracil, with a particular focus on their effects on reproduction in rats. She completed her B.Sc. in Zoology from Al-Azhar University in May 1996, graduating with a “very good” grade. Her postdoctoral research includes a six-month fellowship at Tokai University, Japan, in the Department of Bioscience, School of Agriculture, from June to December 2014. Additionally, she pursued another six-month postdoctoral fellowship in the Cancer Pharmacology Division at the Indian Institute of Integrative Medicine, Jammu, India, from March to September 2012.

Work experience

She has actively participated in international workshops and conferences, including the Fluorescence Microscopy workshop “FluoMicro@ICGEB” at the International Center for Genetic Engineering and Biotechnology (ICGEB) in New Delhi, India, from October 2nd to 4th, 2019. Additionally, she was a speaker at the 6th Rajabhat University National and International Research and Academic Conference, held virtually on August 17-18, 2020, where she presented her research on the Cancer Chemopreventive Activity of Himalayan Plants. In terms of academic supervision, she has guided Ph.D. student Amr Mohammed Abo-Elhamd Ahmed, an Assistant Researcher at the Department of Aromatic and Medicinal Plants, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt. His research focuses on the biochemical and therapeutic evaluation of selected Lamiaceae family plants for prostate disease treatment.

Research project

She has actively contributed to several local and international research projects, playing key roles in various studies. From 2005 to 2008, she was a member of a National Research Centre (NRC) project investigating the genotoxic effects of environmental pollution and veterinary drugs (Project No. 7110613). Between 2010 and 2013, she participated in an NRC-funded project on the production and evaluation of bioactive metabolites and hypolipidemic agents derived from marine sponge and coral endophytic microorganisms against carcinogenic pathogens, liver, and colon cancer (Project No. 9100302).

Her research extended to environmental toxicology, where she contributed to a Science & Technology Development Fund (STDF) project (2012-2014) evaluating mango byproducts as antioxidants against genetic damage caused by lead pollution (Project No. 4782). From 2017 to 2019, she served as a Co-Principal Investigator (Co-PI) on an NRC project studying the anti-hepatotoxic and antigenotoxic properties of plant extracts and their safety for use (Project No. 11010345). During the same period, she was also a member of an NRC project exploring the effects of nanoparticles in tissue culture applications (Project No. 11030108).

Her expertise further contributed to projects applying OMICS technology to enhance food safety in Egypt (2020-2022, Project No. 12050305) and exploring new pharmaceutical raw materials for prostate disease treatment (2020-2022, Project No. 12060108). Additionally, she collaborated with the Bulgarian Academy of Sciences on a research project (2020-2022) focused on improving the production of therapeutic ingredients in Lamiaceae plants for prostate disease treatment using biotechnology techniques.

Publication

 

  • Zaied FA, Zabal M, Diab KA (2003): Cytogenetic and Imuunogenetic studies of cisplatin and 5-Fluorouracil in rats. Zagazig University Journal, (IX):133–156.
  • Fahmy MA,Diab KA (2009): In vivo genotoxicity studies of cefotaxime.Cytologia, 74 (4):417–425.
  • Diab KA, Hassan ZM. (2011): Assessment of the antigenotoxic activity of white sesame extract (Sesamum indicum) against vincristine induced genotoxicity in mice. Comunicata Scientiae, 2(3)126-134.
  • Diab KA and Aboul-Ela E I (2012): In vivo comparative studies on antigenotoxicity of date palm (Phoenix dactylifera L.) pits extract against DNA damage induced by N-Nitroso-N-methylurea in mice. Toxicology International, 19 (3):279-286.
  • Diab KA,Elmakawy AI, Abd El-Moneim OM, Sharaf HA (2012): Assessment of genotoxicity and histopathological changes induced by polyethylene glycol (PEG 6000) in male mice.  Journal of Cytology & Histology, 3(5): 153.
  • Khalil WKB, Ghal IS, Diab KA,Elmakawy AI (2014): Antitumor activity of Moringaoleifera leaf extract against Ehrlich solid tumor. International Journal of Pharmacy, 4(3): 68-82.
  • Elmakawy AI, Abd El-Moneim OM, Diab KA,Sharaf HA (2014) Evaluation of male-mediated reproductive toxicity induced by polyethylene glycol in mice. World Applied Sciences Journal, 31 (8): 1478-1487.