Assist Prof Dr.Ching-Yi Lin ,Cleveland Clinic,Excellence in Research
Dr. Ching-Yi Lin is an esteemed Associate Professor at the Cleveland Clinic, renowned for her excellence in research. Her work focuses on advancing medical science and improving patient outcomes through innovative research methodologies and clinical applications. Dr. Lin’s contributions to the field have been widely recognized, making her a leading figure in her specialty.
Profile:
Scopus
Education
I completed my undergraduate studies at National Chung-Hsing University in Taiwan, where I earned a Bachelor of Science in Veterinary Medicine in 1993. Following this, I pursued a Master of Science in Veterinary Virology at the same institution, graduating in 1995. Building on this foundation, I obtained my Ph.D. in Molecular Medicine from National Taiwan University in 2001. To further specialize my expertise, I undertook postdoctoral training in Neurosciences at the University of California, Irvine, where I completed the program in 2004.
Positions, Scientific Appointments, and Honors:
Fellowships, Honors, Certifications, and Society Memberships:
- Certificate of Excellence in Reviewing (2013) Awarded in recognition of an outstanding contribution to the quality of the journal Experimental Neurology.
Nominated by UCI Undergraduates (2007) Recognized by University of California, Irvine undergraduates for significantly influencing their career development.
Faculty Career Development Award (2005) Received from the University of California, Irvine, acknowledging exceptional promise in a faculty career.
Contributions to Science:
Functional impairments following spinal cord injury (SCI) represent a significant clinical challenge, particularly due to the difficulty in effectively treating such injuries. Our research has focused on developing and refining nerve regeneration strategies to repair injured spinal cord tissues. By combining peripheral nerve grafts (PNG) with acidic fibroblast growth factor (aFGF), we have demonstrated partial success in a T8 spinal cord-transected rat model. Our studies have shown this combined treatment approach to 1) restore muscle mass and the slow phenotype of the soleus muscle, 2) facilitate spinal axon regrowth, including serotonergic (5-HT) fibers, and 3) improve hindlimb locomotion. Furthermore, by adding chondroitinase to this treatment regimen, we have enhanced the regeneration of brainstem and propriospinal axons across extensive transection lesions, leading to significantly improved urinary function.
publications:
- The Spatiotemporal Expression of SOCS3 in the Brainstem and Spinal Cord of Amyotrophic Lateral Sclerosis Mice” (Lin et al., 2024): This study explores how SOCS3, a suppressor of cytokine signaling, is expressed over time in the brainstem and spinal cord of ALS (Amyotrophic Lateral Sclerosis) mice. Understanding SOCS3 expression could provide insights into its role in neurodegenerative diseases.
- “Upregulated 5-HT1A Receptors Regulate Lower Urinary Tract Function in Rats after Complete Spinal Cord Injury” (Lin et al., 2023): This paper investigates how increased 5-HT1A serotonin receptors affect urinary function following a complete spinal cord injury in rats, suggesting potential therapeutic targets for improving urinary control in SCI patients.
- “Improvement of Lower Urinary Tract Function by a Selective Serotonin 5-HT1A Receptor Agonist, NLX-112, after Chronic Spinal Cord Injury” (Lin et al., 2020): The research discusses the effects of NLX-112, a selective agonist for the 5-HT1A receptor, on enhancing urinary tract function in chronic SCI models, highlighting a promising treatment strategy.
- “Differential Adaptations of the Musculoskeletal System after Spinal Cord Contusion and Transection in Rats” (Lin et al., 2018): This study examines how different types of spinal cord injuries (contusion vs. transection) impact musculoskeletal adaptations, which is crucial for understanding recovery and rehabilitation processes.
- “Neuron-specific HuR-deficient Mice Spontaneously Develop Motor Neuron Disease” (Sun et al., 2018): The paper investigates motor neuron disease development in mice lacking HuR (an RNA-binding protein), contributing to the understanding of genetic factors in motor neuron diseases.
- “Combinatory Repair Strategy to Promote Axon Regeneration and Functional Recovery after Chronic Spinal Cord Injury” (Depaul et al., 2017): This research explores a combination of therapies to enhance axon regeneration and functional recovery in chronic SCI, potentially leading to more effective treatment approaches.
- “Mitochondrial STAT3 is Negatively Regulated by SOCS3 and Upregulated after Spinal Cord Injury” (Park et al., 2016): This paper focuses on how SOCS3 regulates mitochondrial STAT3 levels following spinal cord injury, which could be relevant for developing interventions to improve mitochondrial function post-injury.
- “Peripheral Nerve Transplantation Combined with Acidic Fibroblast Growth Factor and Chondroitinase Induces Regeneration and Improves Urinary Function in Complete Spinal Cord Transected Adult Mice” (DePaul et al., 2015): The study assesses the combined effect of peripheral nerve transplantation and specific growth factors on spinal cord regeneration and urinary function recovery in mice.
- “Effects of Reducing Suppressors of Cytokine Signaling-3 (SOCS3) Expression on Dendritic Outgrowth and Demyelination after Spinal Cord Injury” (Park et al., 2015): This paper evaluates how decreasing SOCS3 expression affects dendritic outgrowth and demyelination, offering potential avenues for enhancing neuronal repair and recovery.
- “Differential Intensity-dependent Effects of Magnetic Stimulation on the Longest Neurites and Shorter Dendrites in Neuroscreen-1 Cells” (Lin et al., 2015): The research examines how varying magnetic stimulation intensities affect neurite and dendrite growth in cell models, which may inform therapeutic approaches using magnetic stimulation.