Prof. Dr. Dominique BREMOND-GIGNAC | Congenital Aniridia | Best Researcher Award
University Hospital Necker Enfants malades | France
Dominique Sandra Bremond-Gignac is a distinguished Professor of Ophthalmology and Head of the Ophthalmology Department at University Hospital Necker Enfants-malades, Paris, with a pediatric ophthalmology subspecialty. She leads the OPHTARA Rare Eye Diseases Center coordinating multiple French centers and serves as Head of the CLAIROP Clinical Research Center accredited by Europe EVI-CT, overseeing numerous clinical research protocols. She is affiliated with Paris Cité University and Sorbonne Paris Cité University and contributes to INSERM research in ocular physiopathology and clinical development. Prof. Bremond-Gignac has extensive experience in training medical students, residents, and orthoptists, and holds leadership positions in European and international ophthalmology societies, including WSPOS, EVER, and IMI. Her clinical expertise spans anterior segment surgery, strabismus, oculoplastics, and management of rare and congenital eye diseases. She has over two hundred PubMed-indexed publications and is recognized for her contributions to pediatric ophthalmology, clinical research, and medical education worldwide.
Profile
ORCID
Education
Prof. Bremond-Gignac received her medical training at Paris V University, completing her MD with a medal and specialization in ophthalmology. She holds a Master’s degree in Pharmacology and a second Master’s in Medical Imaging, complementing her clinical expertise with research proficiency. She pursued a PhD in Anatomy at Paris V University, earning distinctions from the examining jury. Her advanced training includes international research experiences, including six months at Manhattan Eye Ear and Throat Hospital in New York and a postgraduate research year at INSERM Unit 598 focused on the ocular surface. She also obtained the European Board of Ophthalmology diploma and completed hospital management training at the EMAMH School of Hospital Management, Paris. Her education combines rigorous medical, surgical, and research training, integrating clinical care with translational ophthalmology research. This foundation supports her leadership in pediatric ophthalmology, rare eye disease management, and clinical research coordination.
Experience
Prof. Bremond-Gignac began her career as a university assistant in ophthalmology and anatomy at Paris, followed by a fellowship in Paris University Hospitals’ ophthalmology departments. She progressed to associate professor at University Hospital R. Debré and later became a full professor of ophthalmology. She currently heads the Ophthalmology Department at University Hospital Necker Enfants-malades, overseeing pediatric clinical care, surgical interventions, and training programs for medical students, residents, and orthoptists. She leads the CLAIROP Clinical Research Center, coordinating phase I-III clinical trials, and directs the OPHTARA Rare Eye Diseases Center, managing national networks for rare ocular conditions. Her professional experience spans clinical practice, surgical expertise in anterior segment, strabismus, and oculoplastics, and leadership in research and hospital management. She is an expert advisor to French ministries and European agencies and holds key roles in international ophthalmology societies, combining administrative, educational, research, and clinical expertise to advance pediatric ophthalmology and ocular disease research.
Awards and Honors
Prof. Bremond-Gignac has been widely recognized for her contributions to ophthalmology and medical education. She was decorated Chevalier de l’Ordre des Palmes Académiques by the President of her university and later received the Chevalier de la Légion d’Honneur for her outstanding service in medicine. She earned the Al Biglan Medal from Pittsburgh University with a dedicated lecture recognizing her clinical and research achievements. She is also a distinguished award member of the American Academy of Ophthalmology and received the Gold Medal Distinction from the Moroccan Society of Ophthalmology. Beyond formal awards, she is widely acknowledged for her leadership in European and international ophthalmology societies, her role in coordinating rare eye disease networks, and her contributions to clinical research and medical education. Her honors reflect her dedication to advancing pediatric ophthalmology, fostering research collaborations, and mentoring the next generation of ophthalmologists and clinical scientists across Europe and internationally.
Research Focus
Prof. Bremond-Gignac’s research focuses on pediatric ophthalmology, rare eye diseases, and ocular physiopathology with translational applications. She leads clinical trials in the CLAIROP Research Center, addressing innovative therapies across phase I to III studies, and coordinates the OPHTARA Rare Eye Diseases Center to advance clinical research for conditions such as aniridia, congenital ocular anomalies, and progressive myopia. Her research integrates imaging, pharmacology, and surgical innovations to improve diagnosis, treatment, and patient outcomes. She collaborates nationally and internationally, contributing to European research networks and advisory boards. She also investigates ocular surface diseases and anterior segment pathologies, translating laboratory findings into clinical interventions. Prof. Bremond-Gignac mentors students and residents in clinical research methods and fosters multidisciplinary approaches linking ophthalmology, genetics, and public health. Her work bridges scientific discovery and patient care, emphasizing evidence-based interventions, early diagnosis of rare ocular conditions, and the development of novel therapies to enhance visual function and quality of life in children with complex eye diseases.
Publications
Title: Genotype-phenotype correlations of COL2A1 and COL11A1 patients
Year: 2025
Title: Cystadrops® Eye Drops for the Management of Ocular Cystinosis in Patients Aged 6 Months to < 2 Years
Year: 2025
Title: Fluctuations in angle lambda with the pupil diameter and correlations with biometric values in a healthy population
Year: 2025
Title: 12-month outcomes after voretigene neparvovec gene therapy in paediatric patients with RPE65-mediated inherited retinal dystrophy
Year: 2025
Title: Glaucome de l’aniridie congénitale liée au gène PAX6 : une revue de la littérature
Year: 2025
Title: Protocole national de diagnostic et de soin pour la prise en charge de la rétinopathie du prématuré : résumé pour le médecin traitant et le généraliste
Year: 2025
Conclusion
Prof. Dominique Sandra Bremond-Gignac is a global leader in pediatric ophthalmology and rare eye disease research, seamlessly integrating clinical practice, research excellence, and academic mentorship, recognized for her innovative contributions to ocular therapeutics, training future ophthalmologists, and shaping international ophthalmology standards through leadership roles in research networks and professional societies.