Agota Apati | Stem Cell Based Disease Modelling | Best Researcher Award

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Dr. Agota Apati | Stem Cell Based Disease Modelling | Best Researcher Award

Dr. Ágota Apáti, PhD, DSc, is a distinguished Hungarian molecular biologist and Senior Research Associate at the Institute of Molecular Life Sciences, Research Centre for Natural Sciences. She leads the Pluripotent Stem Cell Laboratory and is renowned for establishing Hungary’s first human pluripotent stem cell lab. With over 70 publications and an H-index of 25, her work is widely recognized internationally. Dr. Apáti’s research encompasses human iPSC-derived disease models, membrane transporters, and cellular signaling pathways, with implications in schizophrenia, diabetes, and rare syndromes. She has supervised numerous PhD students and maintains active roles in both national and international scientific societies. Her commitment to translational stem cell research and ethical scientific practice positions her as a leading figure in the field of regenerative medicine and cellular therapeutics.

Profile

🎓 Education

Dr. Ágota Apáti holds a Master of Science (MSc) degree in Chemistry from Eötvös Loránd University of Sciences, Budapest (1984–1989). She later pursued doctoral studies and earned her PhD from Semmelweis Medical University (1998–2003), focusing on molecular and cellular aspects of hematology and immunology. Her academic training blends rigorous biochemical education with advanced medical sciences, establishing a solid foundation for her research career in stem cell biology and cellular therapeutics. Through continuous engagement in teaching and supervising graduate students, she has also remained an integral part of academic development at Hungary’s premier institutions. Her strong interdisciplinary background supports her work on complex cellular processes and disease modeling, and she is also a Doctor of Science (DSc, 2024) from the Hungarian Academy of Sciences—an honor awarded for substantial contributions to biomedical research in Hungary.

🧪 Experience

With over three decades of research experience, Dr. Ágota Apáti began her scientific career as a Research Fellow at Semmelweis Medical University (1989–1993). She progressed through multiple institutions, including the National Institute of Haematology and Immunology (1993–2004) and the National Blood Service (2005–2013), where she led various molecular biology projects. Between 2013 and 2023, she was a Senior Research Associate and lab head at the Institute of Enzymology, Hungarian Academy of Sciences. Since 2023, she continues her leadership as Laboratory Head at the Institute of Molecular Life Sciences under HUNREN. She has consistently taught and mentored postgraduate students in biochemistry, hematology, immunology, and membrane biology. Dr. Apáti’s collaborative and interdisciplinary projects have helped develop multiple disease models and cellular assays. Her scientific leadership has been instrumental in expanding Hungary’s role in cutting-edge stem cell research and molecular diagnostics.

🏅 Awards and Honors

Dr. Ágota Apáti has been recognized both nationally and internationally for her contributions to biomedical research. Early in her career, she received the prestigious UNIDO award during the ICRO course on RNA structure and function in Trieste, Italy (1994). In 2024, she was awarded the Doctor of Science (DSc) degree by the Hungarian Academy of Sciences—a distinguished title granted to researchers with a substantial, impactful body of scientific work. Her membership in renowned scientific organizations, such as the International Society for Stem Cell Research (ISSCR), Hungarian Society of Biology, Hungarian Society of Biochemistry, and the Hungarian Medical Research Council’s Ethical Board for Human Reproduction, underscores her stature in the field. These accolades not only reflect her scientific excellence but also her contributions to ethical research practice, public health, and mentoring within the scientific community, cementing her reputation as a key contributor to molecular life sciences.

🔬 Research Focus

Dr. Apáti’s research centers on pluripotent stem cells, disease modeling, and cellular signaling. She specializes in generating and differentiating human induced pluripotent stem cells (iPSCs) into neuronal, cardiac, mesenchymal, and endothelial lineages. Her work extends into disease modeling for schizophrenia, arteriosclerosis, diabetes, DiGeorge syndrome, and Frank-Ter Haar syndrome using patient-derived iPSC lines and CRISPR-based genome editing. She has developed cellular reporter systems to study membrane transporter function and calcium signaling pathways, significantly advancing understanding in neuropsychiatric and cardiovascular disorders. Through integrative omics and 3D organoid models, Dr. Apáti’s lab explores metabolic and genetic dysregulation in human pathologies. Her translational research aims to identify drug targets and therapeutic strategies using patient-specific cell lines. She also investigates multidrug resistance in stem cells and cancer, contributing to better clinical interventions. Her multidisciplinary projects bridge fundamental biology with clinical relevance, making her a vital contributor to regenerative medicine and personalized therapy.

✅ Conclusion

Dr. Ágota Apáti is a trailblazing scientist whose pioneering work in human stem cell research, disease modeling, and membrane biology continues to shape translational medicine, with a sustained commitment to research excellence, scientific mentorship, and ethical innovation in biomedical sciences.

Publications

  • Haloperidol, Olanzapine, and Risperidone Induce Morphological Changes in an In Vitro Model of Human Hippocampal Neurogenesis

    Biomolecules
    2024-06 | Journal article | Author
    DOI: 10.3390/biom14060688
    CONTRIBUTORS: Bálint Jezsó; Sára Kálmán; Kiara Gitta Farkas; Edit Hathy; Katalin Vincze; Dzsenifer Kovács-Schoblocher; Julianna Lilienberg; Csongor Tordai; Zsofia Nemoda; László Homolya et al.

  • Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene

    Genes
    2022-10 | Journal article | Author
    DOI: 10.3390/genes13111925
    CONTRIBUTORS: Dóra Reé; Ábel Fóthi; Nóra Varga; Orsolya Kolacsek; Tamas Orban; Agota Apat

  • A Novel Cell-Based Model for a Rare Disease: The Tks4-KO Human Embryonic Stem Cell Line as a Frank-Ter Haar Syndrome Model System

    International Journal of Molecular Sciences
    2022-08 | Journal article | Author
    DOI: 10.3390/ijms23158803
    CONTRIBUTORS: Loretta László; Hédi Maczelka; Tamás Takács; Anita Kurilla; Álmos Tilajka; László Buday; Vas Virag; Agota Apati
  • Synthesis and Systematic Investigation of Lepidiline A and Its Gold(I), Silver(I), and Copper(I) Complexes Using In Vitro Cancer Models and Multipotent Stem Cells

 

Jim Jinn-Chyuan Sheu | Precision medicine | Best Researcher Award

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Dr. Jim Jinn-Chyuan Sheu | Precision medicine | Best Researcher Award

Dr. Jim Jinn-Chyuan Sheu is a professor at the Institute of Biomedical Sciences, National Sun Yat-sen University, Taiwan, and an adjunct professor in several prestigious institutions. With a PhD in Life Science from National Tsing-Hua University, his academic and industrial experiences span cancer genetics, precision medicine, and biopharmaceuticals. He has held positions at Johns Hopkins Medical Institutions and Development Center for Biotechnology. His research explores molecular mechanisms underlying diseases such as cancer and endometriosis, employing genome-wide technologies to identify biomarkers and drug targets. He actively contributes to biomedical innovation, translational medicine, and mentorship. Dr. Sheu has received numerous national and international awards, including the Wu-Da-You Memorial Award and Sigma Xi membership. He is also an ambassador for the European Association for Cancer Research. As a prolific researcher and reviewer, he plays key roles in research councils and institutional review boards, helping shape scientific policy and translational biomedical advancements in Taiwan and beyond.

Profile

Education 🎓

Dr. Sheu earned his Ph.D. in Life Science from National Tsing-Hua University, Taiwan, in 2002, where he focused on advanced molecular biology, gene expression regulation, and biomedical research. His doctoral training provided a strong foundation in cancer genetics and systems biology. Earlier, he completed his B.S. in Biology (now Life Science) from Fu-Jen University in 1994, building core competencies in biological sciences and cellular mechanisms. These educational milestones equipped him with theoretical knowledge and technical skills in genomics, proteomics, and cellular signaling, which are now reflected in his research on chromatin remodeling, cancer biomarkers, and therapeutic targets. Through rigorous academic mentorship, Dr. Sheu gained early exposure to multidisciplinary research and critical analysis, fostering his interest in precision medicine. His academic background laid the groundwork for his contributions to biomedical research, drug development, and translational science. These formative years in Taiwan’s top universities underpin his long-standing excellence in scientific discovery and innovation.

Experience 👨‍🏫

Dr. Sheu’s professional experience includes faculty roles and research leadership across academia and industry. He has served as a Professor at National Sun Yat-sen University since 2014 and previously held faculty roles at China Medical University. Internationally, he was a Research Fellow at Johns Hopkins Medical Institutions (2004–2006). Between 2003–2004, he worked in various leadership positions at the Development Center for Biotechnology, including Director of Protein Drugs Division and Project Leader. His postdoctoral and early research roles included work with Dr. Tse-Wen Chang and Dr. Carmay Lim at Academia Sinica. His academic leadership includes roles such as Associate VP of R&D, Chair of the Institute of Biomedical Sciences, and Director of Research Resources at NSYSU. He has reviewed research proposals for numerous hospitals and institutions, served on IRBs, and guided government research policy. His diverse experience bridges basic science, translational research, and biomedical entrepreneurship with national and global impact.

Awards & Recognitions 🏅

Dr. Sheu has received over 30 prestigious awards. In 2023 alone, he earned the Tien-Te Lee Award, NSYSU Outstanding Faculty Award, and top honors at the 37th Joint Biomedical Conference. He previously received the Prof. Chii-Ruey Tzeng Award, Sigma Xi membership (2021), and EACR Ambassador role (2020). His innovation was recognized by Future Tech Award and the 2020 Smart Life Innovation Competition. His studies were featured as Taiwan Research Highlights and F1000Prime recommendations. He was the 2014 recipient of the Wu-Da-You Memorial Award and the IBC Outstanding Scientific Achievement Award. He received the Medical Young Investigator Award in 2009 and the Best Basic Science Award at Johns Hopkins in 2005. As a government-financed scholar to the U.S., his academic excellence has been internationally recognized. He consistently ranks among Taiwan’s top biomedical researchers, illustrating his impact through award-winning research in endometriosis, cancer stemness, diagnostics, and therapeutic innovation.

Research Interests 🔬

Dr. Sheu’s research focuses on cancer genetics and genomics, endometriosis, precision medicine, chromatin remodeling, cytoskeletal dynamics, cell adhesion and invasion, and mechanotransduction. His lab investigates how abnormalities in gene expression and chromatin structure drive disease progression, especially in gynecologic cancers and endometriosis. By applying genome-wide analysis and bioinformatics, his team identifies disease-driving genes and develops novel diagnostic tools and therapeutic strategies. A key interest is the tumor microenvironment and how cytoskeletal networks and nuclear architecture influence cancer stemness and metastasis. His group explores traditional Chinese medicine compounds and stem cell therapies, advancing integrative approaches to medicine. Antibody and vaccine engineering are also integral to his translational pipeline. Funded by NSTC Taiwan and other institutions, his projects target non-invasive diagnostics and biomarker-based interventions. His long-term vision involves bridging molecular biology, clinical application, and therapeutic innovation to impact patient care and global health through interdisciplinary and precision-driven biomedical science.

Publications