Melania Ruggiero | Neuroinflammation | Best Researcher Award

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Dr. Melania Ruggiero | Neuroinflammation | Best Researcher Award

Dr. Melania Ruggiero is a postdoctoral researcher at the University of Bari Aldo Moro, specializing in neuroinflammation and neurodegenerative diseases. She earned her Master’s degree in Medical Biotechnology and Nanobiotechnology from the University of Salento in 2020, followed by a PhD in Functional and Applied Genomics and Proteomics from the University of Bari Aldo Moro in 2024. Throughout her academic journey, she has attended specialized training in neuroscience and advanced fluorescence microscopy. Her research focuses on exploring bioactive compounds for neuroprotection, reprogramming astrocytes into neurons, and mitigating neuroinflammatory processes. She has contributed extensively to scientific literature, authoring multiple publications in high-impact journals, and currently serves as a reviewer for journals such as the International Journal of Molecular Sciences and Cells. Dr. Ruggiero actively collaborates with national and international research groups, contributing to innovative approaches in the treatment of neurodegenerative disorders.

Profile

🎓 Education

Dr. Melania Ruggiero’s academic journey began with her Master’s degree in Medical Biotechnology and Nanobiotechnology at the University of Salento (2020), where she gained a strong foundation in molecular biology, biotechnology, and nanomedicine. She subsequently pursued a PhD in Functional and Applied Genomics and Proteomics at the University of Bari Aldo Moro (2024), during which she engaged in extensive research focused on neurodegenerative disorders. Her doctoral studies were enriched by attending specialized courses, including the “Cellular, Behavioural and Cognitive Neuroscience” school and the “Fluomicro@ICGEB-ICGEB Practical Course of Fluorescence Microscopy and High Throughput Imaging.” These programs equipped her with advanced skills in cellular neuroscience, imaging, and data analysis. Her academic training provided a strong interdisciplinary foundation that bridges biotechnology, neuroscience, and clinical research, supporting her ongoing contributions to innovative treatments for neurodegenerative diseases.

🧪 Experience

Dr. Ruggiero’s professional experience encompasses advanced academic research and international collaboration. Currently a postdoctoral researcher at the Department of Biosciences, Biotechnology and Environment at the University of Bari Aldo Moro, she actively investigates neurodegeneration, neuroinflammation, and potential therapeutic interventions. Her research has led to seven completed and five ongoing research projects. Dr. Ruggiero’s expertise includes the study of bioactive compounds for neuroprotection, demonstrating their ability to reduce neuroinflammatory processes and promote astrocyte reprogramming. She has authored numerous peer-reviewed publications and is actively involved in peer-review activities for journals such as International Journal of Molecular Sciences and Cells. Her collaborative network extends across various esteemed institutions, including universities in Italy and Saudi Arabia. Dr. Ruggiero’s experience reflects a commitment to cutting-edge neuroscience research, fostering translational approaches to combat neurodegenerative disorders.

🏅 Awards and Honors

While specific awards are not listed, Dr. Ruggiero’s scholarly contributions demonstrate substantial recognition in the scientific community. Her numerous publications in internationally indexed journals, with a current h-index of 6, signify her growing influence and impact in the field of neuroscience. Serving as a peer reviewer for prestigious journals such as International Journal of Molecular Sciences and Cells highlights her standing as a respected expert. Additionally, her collaborations with multiple international institutions reflect her role as a valued scientific partner in global research networks. Her research findings, particularly on the neuroprotective roles of bioactive compounds and astrocyte reprogramming, position her as a strong candidate for the Best Researcher Award, acknowledging her innovative contributions to neuroscience and neurodegenerative disease research.

🔬 Research Focus

Dr. Ruggiero’s research centers on neuroinflammation and neurodegenerative diseases, with a particular emphasis on bioactive compounds as potential therapeutic agents. Her innovative work has demonstrated that compounds such as resveratrol, vitamin C, irisin, and lactoferrin can reduce astrogliosis and microgliosis, mitigating neuroinflammatory responses that underlie neurodegeneration. Significantly, she has pioneered findings showing that lactoferrin not only attenuates astrocyte reactivity but also reprograms astrocytes into neuronal precursor cells, promoting neurogenesis and counteracting neuronal loss. This groundbreaking research contributes to developing safer, more effective therapies for neurodegenerative disorders, minimizing side effects compared to conventional treatments. Her work integrates cellular biology, molecular neuroscience, and translational medicine, advancing novel therapeutic strategies for conditions such as Alzheimer’s and Parkinson’s disease. Her collaborations across national and international institutions further enhance the multidisciplinary nature and clinical relevance of her research.

✅ Conclusion

Dr. Melania Ruggiero is an emerging leader in neurodegenerative research, whose pioneering work on bioactive compounds and astrocyte reprogramming offers innovative therapeutic avenues, demonstrated through extensive publications, international collaborations, and impactful scientific contributions, making her a strong candidate for the Best Researcher Award.

Publications

Jaqueline Scholz | Prevention – Public Politic | Best Research Article Award

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Dr. Jaqueline Scholz | Prevention – Public Politic | Best Research Article Award

Dr. Jaqueline Ribeiro Scholz, MD, PhD, is a distinguished cardiologist and academic based at the Instituto do Coração (InCor), Universidade de São Paulo, Brazil. Renowned for her pioneering work in tobacco control, Dr. Scholz has made significant contributions to cardiovascular health through clinical innovation, research, and public policy. She directs the Smoking Cessation Program at InCor, offering advanced treatment modalities for tobacco dependency and developing innovative digital tools such as the PAF software and COVID-19 cessation chatbot. Her expertise has been instrumental at state, national, and global levels, including collaborations with the World Health Organization’s Tobacco or Health Program. Dr. Scholz’s commitment extends beyond clinical practice into impactful public health advocacy, contributing to legislation and preventive programs aimed at reducing tobacco-related harm globally. Her work aligns closely with international efforts to combat non-communicable diseases, positioning her as a global leader in preventive cardiology and tobacco cessation.

Profile

🎓 Education

Dr. Jaqueline Scholz received her medical training and specialized education entirely at the prestigious Universidade de São Paulo, Brazil. She completed her Residency in Cardiology at the Instituto do Coração (InCor), gaining extensive clinical expertise in cardiovascular medicine. Pursuing her academic ambitions, she specialized further with a degree in Cardiopneumology at Faculdade de Medicina da USP, equipping her with a comprehensive understanding of cardiopulmonary diseases and their systemic impacts. In 2002, Dr. Scholz earned her PhD in Cardiology from Universidade de São Paulo, focusing her research on the intersection of tobacco use and cardiovascular health. Her academic foundation has underpinned her multidisciplinary approach to clinical care, research, and public health advocacy, blending cutting-edge science with practical interventions aimed at tobacco cessation. This strong educational background has positioned her as a respected authority in preventive cardiology, with a special emphasis on combating the global tobacco epidemic.

🧪 Experience

Dr. Jaqueline Scholz has over three decades of progressive experience in clinical cardiology, research, and public health policy. Since 2003, she has served as Director of the Smoking Cessation Program at Instituto do Coração (InCor), São Paulo, leading innovative cessation strategies, including the development of patient-support technologies like the PAF software and a COVID-19 chatbot for smokers. Between 1995 and 1996, she contributed her expertise to the São Paulo State Health Department’s Commission on Tobacco Control, directly influencing state-level anti-tobacco policies and campaigns. Earlier, from 1993 to 1996, Dr. Scholz served as a medical collaborator with the World Health Organization’s Tobacco or Health Program, participating in global strategy development for tobacco reduction. Her multifaceted career bridges clinical innovation, technology integration, public health leadership, and international policy advising, marking her as a key figure in tobacco control and preventive cardiovascular care on both national and global stages.

🏅 Awards and Honors

Although specific awards are not listed, Dr. Jaqueline Scholz’s career is marked by distinguished recognition through her leadership roles and global collaborations. Being appointed as Director of the Smoking Cessation Program at one of Brazil’s most prestigious cardiology institutes reflects professional excellence. Her selection to serve on the São Paulo State Commission on Tobacco Control and as a collaborator with the World Health Organization underscores her expertise and international reputation in tobacco control. Her innovative development of patient-centric tools such as the PAF software and the COVID-19 cessation chatbot has further garnered professional acclaim. Dr. Scholz’s extensive involvement with leading health organizations and her continuous contributions to public health policy highlight the respect and trust she commands within the cardiovascular and tobacco control communities. Her work aligns with the global health agenda, earning her recognition as a leading advocate and innovator in preventive cardiology and tobacco harm reduction.

🔬 Research Focus

Dr. Jaqueline Scholz’s research focuses on tobacco dependency treatment, smoking cessation strategies, and their direct impact on cardiovascular health outcomes. Her work bridges clinical practice, digital health innovation, and public health policy to develop effective, scalable interventions for tobacco users. At InCor, she leads studies on novel cessation methodologies, including the integration of digital platforms like the PAF software and automated chatbots to enhance patient support, particularly during public health crises like COVID-19. She has contributed to global tobacco control frameworks through collaborations with the World Health Organization, emphasizing the cardiovascular consequences of smoking and advocating for robust public health responses. Her research also informs state-level policy development, contributing to evidence-based regulations and campaigns targeting smoking reduction. Dr. Scholz’s work aims to reduce the global burden of cardiovascular diseases by addressing one of its leading risk factors—tobacco use—through innovative, patient-centered, and policy-driven approaches.

✅ Conclusion

Dr. Jaqueline Scholz is a globally recognized cardiologist whose innovative clinical work, pioneering research, and leadership in public health policy have made substantial contributions to tobacco cessation and cardiovascular health, aligning with global efforts to reduce smoking-related morbidity and mortality.

Publications

  • Nicotine Dependence in a Banned Market: Biomarker Evidence from E-Cigarette Users in São Paulo, Brazil

    International Journal of Environmental Research and Public Health
    2025-06-19 | Journal article
    DOI: 10.3390/ijerph22060960
    CONTRIBUTORS: Jaqueline Ribeiro Scholz; Elaine Cristine D’Amico; Juliana Takitane; Daniele Mayumi Sinagawa; João Mauricio Castaldelli-Maia; Marcelo Filonzi dos Santos; Rodrigo Alves de Oliveira; Guilherme Vinicius Marques; Eric Nagamine Lima; Diana Fernanda Lasso Rodriguez et al.

  • Smoking cessation decreases arterial blood pressure in hypertensive smokers: A subgroup analysis of the randomized controlled trial GENTSMOKING

    Tobacco Induced Diseases
    2024-05-16 | Journal article
    DOI: 10.18332/tid/186853
    CONTRIBUTORS: Patricia V. Gaya; Guilherme Wesley P. Fonseca; Lucas Tsuyoshi Tanji; Tania O. Abe; Maria Janieire N. N. Alves; Paulo Caleb Junior de Lima Santos; Fernanda M. Consolim Colombo; Jaqueline R. Scholz

  • Posicionamento da Sociedade Brasileira de Cardiologia sobre o Uso de Dispositivos Eletrônicos para Fumar – 2024

    Arquivos Brasileiros de Cardiologia
    2024-02-08 | Journal article
    DOI: 10.36660/abc.20240063
    CONTRIBUTORS: Jaqueline R. Scholz; Deborah Carvalho Malta; Antonio Aurélio de Paiva Fagundes, Júnior; Ricardo Pavanello; Gerson Luiz Bredt, Júnior; Mário de Seixas Rocha

  • Evaluation of the nicotine metabolite ratio in smoking patients treated with varenicline and bupropion

    Frontiers in Pharmacology
    2022 | Journal article
    DOI: 10.3389/fphar.2022.900112

    EID:

    2-s2.0-85135484127

    Part of ISSN: 16639812
    CONTRIBUTORS: Tomaz, P.R.X.; Gonçalves, T.S.; Santos, J.R.; Scholz, J.; Abe, T.O.; Gaya, P.V.; Figueiredo, E.C.; de Faria, H.D.; Martins, I.; Pego, A.M.F. et al

Avhasei Dorothy Meregi | Cognitive Rehabilitation | Best Researcher Award

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Avhasei Dorothy Meregi | Cognitive Rehabilitation | Best Researcher Award

Mrs. Avhasei Dorothy Meregi, Department of Biokinetics, Recreation and Sport Science, Faculty of Health Sciences, University of Venda, South Africa

Mrs. Avhasei Dorothy Meregi is a dedicated sports scientist from Tshiulungoma village, Limpopo, South Africa 🇿🇦. She holds a BSc in Sport Science 🎓 from the University of Venda, an MPhil in Sport Science 🏃‍♀️ from the University of Johannesburg, and is pursuing her PhD in Human Movement Sciences at the University of Zululand 📚. With extensive experience in sports performance assessment, adolescent health, and athlete development, she has contributed to both research and academia 👩‍🏫. A fluent speaker of Sepedi, Tshivenda, and English 🗣️, she is passionate about inclusive sports education and has made significant impacts through her teaching and community engagement 💪🌍.

Profile

Education 🎓

Mrs. Avhasei Dorothy Meregi began her academic journey at Liivha Combined School, where she completed Grade 12 in 2006 🎓. She earned a BSc in Sport Science (Honours equivalent) from the University of Venda in 2011 🏃‍♀️, followed by an Advanced Diploma in Sport Management from the same university in 2019 📊. That same year, she obtained a Postgraduate Diploma in Higher Education (Teaching and Learning) from the University of Stellenbosch 🎓📚. Her passion for sports science led her to complete an MPhil in Sport Science at the University of Johannesburg in 2019 🧠🏅.

Experience 👨‍🏫

Mrs. Avhasei Dorothy Meregi has built a dynamic professional path rooted in sports science and athlete development. Her journey includes an impactful internship at the National Research Foundation 🎓 and hands-on experience at the Limpopo Academy of Sports 🏟️. She has developed specialized training and nutrition programs 🍎💪, conducted detailed performance assessments 📊, and contributed to athlete monitoring and development at the provincial level. Her practical experience with diverse sports codes and commitment to evidence-based strategies underscore her dedication to enhancing athletic performance and promoting physical health in communities 🤝⚽.

Research Interests 🔬

Mrs. Avhasei Dorothy Meregi’s research focus lies in adaptive physical activity, adolescent health, and inclusive sports participation. Her work, including the study titled “We Just Improvise”, explores the barriers and innovative approaches used by teachers to engage learners with intellectual disabilities in rural South African communities 🌍. She emphasizes equitable access to sports 🏀 and the importance of tailored physical education programs 🏫. Her research contributes significantly to disability-inclusive education, sport science, and community-based interventions 👩‍🔬🤸‍♂️. Through qualitative insights and practical strategies, she advances health promotion and social inclusion for vulnerable youth populations.

Publications 

  • We Just Improvise”: Exploring Teachers’ Perspectives on Sport Participation for Learners with Intellectual Disabilities in Rural South Africa

Aymane Edder | Ai and Iot in Healthcare | Best Researcher Award

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Mr. Aymane Edder | Ai and Iot in Healthcare | Best Researcher Award

Edder Aymane is a highly motivated third-year PhD student specializing in Tiny Machine Learning (TinyML) for vital signs monitoring. Based in Casablanca, Morocco, his research focuses on developing efficient machine learning models deployable on embedded systems to analyze and interpret biomedical data in real-time, ultimately enhancing health monitoring and diagnostics. His technical expertise spans TinyML, embedded systems, IoT, biomedical signal processing, model optimization, and programming languages such as Python, C/C++, and MATLAB. Edder has gained hands-on experience through internships at ERAMEDIC, CHU Ibn Rochd, MEDICINA, and BRET LAB, contributing to various healthcare technology projects including the development of remote monitoring prototypes for COVID-19 patients. His academic journey reflects a strong foundation in biomedical engineering, industrial science physics, and medical analysis, complemented by extensive practical skills. Fluent in Arabic and English, with intermediate proficiency in French, Edder Aymane is committed to advancing real-time healthcare solutions through innovative machine learning applications.

Profile

🎓 Education

Edder Aymane’s educational path demonstrates a strong interdisciplinary foundation. He is currently pursuing his PhD at UM6SS, Casablanca (2023–present), focusing on TinyML applications for healthcare monitoring. He earned his Engineering Degree in Biomedical Sciences from ENSAM Rabat (2019–2022), where he worked on practical projects such as remote vital parameters monitoring for COVID-19 patients. Prior to that, he completed preparatory classes in Industrial Science Physics (PSI) (2017–2019), which equipped him with a strong base in physics and engineering principles. Throughout his academic training, Edder engaged in various internships at leading healthcare and research institutions, including ERAMEDIC, CHU Ibn Rochd, and MEDICINA, where he gained real-world experience in laboratory analysis, medical device installation, and healthcare informatics. His academic career combines theoretical learning with hands-on practice, positioning him well for advanced research in biomedical machine learning and embedded systems.

🧪 Experience

Edder Aymane has developed extensive professional experience through diverse internships and research projects related to healthcare technology and biomedical engineering. At ERAMEDIC (July–Sept 2021), he contributed to the installation of Neuro-Navigation Surgery Software and pre-installation of radiology rooms. During his time at MEDICINA (July–Aug 2020), he performed internal and external quality control of biochemistry, hematology, and serology automat systems. At CHU Ibn Rochd, he was involved in setting up COVID-19 services and developing remote monitoring prototypes for vital signs during the pandemic. His end-of-studies internship at BRET LAB (2023–present) further strengthened his research expertise in biomedical signal processing and TinyML model development. These experiences allowed him to apply his technical skills in embedded systems, IoT integration, and machine learning, giving him a well-rounded profile in both research and applied biomedical technologies.

🏅 Awards and Honors

While specific formal awards and honors are not listed, Edder Aymane’s consistent selection for highly technical internships and research projects at reputable healthcare institutions demonstrates recognition of his expertise and potential. His involvement in cutting-edge projects such as the development of a prototype remote vital parameters monitor for COVID-19, installation of complex neuro-navigation systems, and leadership roles during his internships indicate a high level of trust from supervisors and collaborators. His acceptance into the PhD program at UM6SS to work on emerging fields like TinyML reflects both academic and professional acknowledgment of his abilities. Additionally, his multidisciplinary skillset in machine learning, embedded systems, and biomedical signal processing showcases his outstanding technical competency, positioning him as a promising researcher poised for future honors as his academic career progresses.

🔬 Research Focus

Edder Aymane’s research focuses on leveraging Tiny Machine Learning (TinyML) for real-time health monitoring and diagnostics. His work involves developing highly efficient machine learning models optimized for deployment on embedded systems with limited computational resources. Specifically, he focuses on analyzing biomedical signals such as ECG data, enabling continuous monitoring of vital signs directly from wearable or portable devices. His research integrates advanced signal processing techniques, noise filtering, IoT protocols (MQTT, CoAP, BLE), and real-time data interpretation, contributing to more accessible, scalable healthcare solutions. By combining biomedical engineering with embedded AI, Edder aims to bridge the gap between sophisticated machine learning models and practical, low-power medical devices. His work has significant implications for early diagnostics, remote patient monitoring, and scalable healthcare delivery, particularly in resource-limited settings. This research contributes to the growing field of personalized, preventive healthcare powered by intelligent, real-time monitoring systems.

✅ Conclusion

Edder Aymane is an emerging biomedical researcher specializing in TinyML for vital signs monitoring, with a strong foundation in biomedical engineering, embedded systems, IoT, and machine learning; his hands-on experience across leading healthcare institutions and advanced research in real-time healthcare monitoring position him as a promising innovator poised to advance scalable, efficient, and accessible healthcare solutions through cutting-edge embedded AI technologies.

Publications

Marianne Rizk-Hildbrand | Psychology | Best Researcher Award

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Mrs. Marianne Rizk-Hildbrand | Psychology | Best Researcher Award

She is completing her PhD at KJPP Zürich, focusing on youth suicide prevention through the AdoASSIP project. Her professional experience spans various roles within KJPP Zürich, including emergency care, inpatient therapy, diagnostics, family counseling, and research. Earlier, she worked in diverse sectors such as aviation, hospitality, and legal assistance, demonstrating adaptability and strong interpersonal skills. Alongside her clinical and research commitments, she has been active in volunteer work, serving as a translator for refugee projects. Her multilingual proficiency in German, English, French, and Egyptian Arabic allows her to connect effectively with diverse populations. She is recognized as an AdoASSIP instructor, supervisor, and therapist, reflecting her advanced therapeutic competencies. She embodies a rare combination of academic rigor, clinical expertise, and cross-cultural sensitivity, preparing her for a leading role in adolescent mental health care and research.

Profile

🎓 Education

Her academic journey began with a Bachelor of Science in Psychology (2014-2018) from the University of Zürich, supplemented by an exchange semester at Humboldt University, Berlin (2019). She then pursued a Master of Science in Psychology at the University of Zürich (2018-2021), successfully completed in HS2020. Additionally, she earned multiple certifications in AdoASSIP therapy, including supervisor and instructor credentials between 2022 and 2024. In December 2024, she attained the title of federally recognized psychotherapist (IPKJ). Currently, she is finalizing her PhD (expected 2025), focusing on youth suicidality. Her earlier studies include the Gymnasium at Kantonsschule Hottingen (2006–2010), Bachelor of Law studies (incomplete, 2011–2014), and primary education in Opfikon. This strong educational background provides her with a solid foundation in both psychological theory and clinical practice, which she continuously enriches with ongoing training and research involvement, particularly in adolescent mental health, suicidality, and peer influence dynamics.

🧪 Experience

Her clinical experience is extensive, primarily at KJPP Zürich since 2020. As a doctoral student (2021-2024) and psychologist on youth wards (2023-2024), she conducted diagnostics, therapy, psychodiagnostic testing, family consultations, and managed clinical documentation. She contributed significantly to research, including master’s student supervision and publishing scholarly articles. Earlier roles include psychologist at the emergency centre KANT (2021-2023), where she handled acute psychiatric assessments and crisis interventions. She previously held positions in other sectors such as aviation (Swissport), hospitality (Migros Fitnesspark), legal assistance (Wenger Plattner), and customer service (Jelmoli), which enriched her communication and organizational skills. Additionally, she volunteered as a translator for refugees, showcasing her humanitarian commitment. Her interdisciplinary and multicultural experience enables her to work effectively with diverse patient populations, while her research roles highlight her commitment to advancing evidence-based interventions for youth at risk of suicide.

🏅 Awards and Honors

While no formal awards are explicitly mentioned, her series of professional certifications reflect significant achievements in her field. She became a certified AdoASSIP therapist (2022), supervisor (2023), and instructor (2024), underlining her deep specialization in evidence-based suicide prevention methods for adolescents. Her admission to the federally recognized psychotherapy program (IPKJ) and successful completion in December 2024 further demonstrate her recognized competence in clinical psychotherapy. The selection to pursue a PhD focused on adolescent suicidality at KJPP Zürich itself indicates academic merit and research potential. In addition, her consistent involvement in both clinical practice and cutting-edge research within one of Switzerland’s leading psychiatric institutions highlights her professional excellence. Her voluntary contributions to refugee support services reflect an ongoing commitment to social responsibility and community engagement, qualities often acknowledged and respected in healthcare professionals and researchers alike.

🔬 Research Focus

Her research centers on adolescent suicidality, particularly within the AdoASSIP program, a specialized intervention for youth following suicide attempts. Her doctoral dissertation (to be defended in September 2025) investigates complex factors such as body shaming, violence, self-care, and the social contagion of suicidality among peers. This work contributes to a nuanced understanding of the psychosocial dynamics leading to youth suicide attempts. She is deeply involved in intervention research, combining clinical practice with empirical investigation, which allows her to test, refine, and implement effective therapeutic strategies. Her work also involves supervising master’s theses, publishing scientific papers, and contributing to ethical and methodological standards within clinical research. By integrating her practical experience with academic inquiry, she addresses pressing public health concerns and advances therapeutic techniques aimed at reducing youth suicidality. Her research holds significant potential to inform policy, clinical practice, and future studies in adolescent mental health.

✅ Conclusion

Through a combination of advanced clinical training, focused research on adolescent suicidality, and diverse professional experiences, she emerges as a highly competent psychologist and researcher poised to make impactful contributions to youth mental health care, suicide prevention, and evidence-based therapeutic interventions within multicultural contexts.

Publications

  • The Body as a Battleground: A Qualitative Study of the Impact of Violence, Body Shaming, and Self-Harm in Adolescents with a History of Suicide Attempts

    International Journal of Environmental Research and Public Health
    2025-05-30 | Journal article
    DOI: 10.3390/ijerph22060859
    CONTRIBUTORS: Marianne Rizk-Hildbrand; Tara Semple; Martina Preisig; Isabelle Haeberling; Lukasz Smigielski; Dagmar Pauli; Susanne Walitza; Birgit Kleim; Gregor E. Berger

Vicente A. Domingo-Sanz | Motor system and visual system | Best Innovator Award

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Mr. Vicente A. Domingo-Sanz | Motor system and visual system | Best Innovator Award

Vicente A. Domingo-Sanz is a Spanish motor therapist specializing in the integration of primitive reflexes. Based in Algemesí (Valencia), Spain, he works at Centro Optométrico Montrull, a leading visual therapy center. Over the years, he has combined his expertise in social education, business administration, neuroscience, and neuro-physiological psychology to develop innovative therapeutic approaches. As the creator of Primitive Reflex Integration Therapy DM Primary Reflexes, he has contributed significantly to the understanding of primitive reflexes and their impact on motor and visual functions. His research has been widely published in respected journals, focusing on the links between persistent primitive reflexes, visual system development, and motor functioning. With extensive training in various international reflex integration methodologies, including INPP, BRMT, and MNRI, Domingo-Sanz brings a multidisciplinary perspective to his clinical practice, supporting children and adolescents with developmental challenges through personalized therapeutic interventions that promote neuro-motor development and functional integration.

Profile

🎓 Education

Vicente A. Domingo-Sanz has pursued comprehensive and multidisciplinary academic training. In 2009, he earned his qualification as a Social Educator from UNED Valencia, focusing on work with special needs populations. In 2012, he completed an Executive MBA at ESTEMA-European University of Madrid, expanding his management and administrative skills. Recognizing the need for deeper scientific understanding, in 2019 he completed a Master’s Degree in Experimental and Clinical Neuroscience from the University of Murcia, focusing on motor neurological functioning. His specialized training includes certification from INPP Spain in 2013, where he studied the integration of primitive reflexes based on neuro-physiological psychology, and from BRMT Spain in 2012, focusing on Blomberg Rhythmic Movement Training for reflex integration. From 2014 to 2019, he was certified as an MNRI Therapist by the Svetlana Masgutova Institute Europe, mastering the MNRI approach. This extensive educational background underpins his expertise in motor therapy and reflex integration.

🧪 Experience

Vicente A. Domingo-Sanz currently works as a motor therapist specializing in the integration of primitive reflexes at Centro Optométrico Montrull in Algemesí, Valencia, Spain. His professional journey reflects a deep commitment to improving the motor, cognitive, and visual functions of individuals, particularly children and adolescents with developmental challenges. Through years of practice, he has successfully combined evidence-based techniques from multiple reflex integration approaches, including INPP, BRMT, and MNRI methodologies. In addition to his clinical practice, he has developed his own therapeutic method, Primitive Reflex Integration Therapy DM Primary Reflexes, which reflects his advanced knowledge and innovative thinking. His hands-on experience with patients complements his academic research, allowing him to translate scientific findings into effective therapeutic strategies. His role involves not only direct patient care but also training, research, and contributing to the scientific community through publications addressing the impact of primitive reflexes on the visual system and motor functions.

🏅 Awards and Honors

Vicente A. Domingo-Sanz’s research centers on the persistence of primitive reflexes and their impact on motor development and visual functions in children and adolescents. His studies examine how unresolved primitive reflexes can influence ocular motility, fixation, visual projection, and overall neurological functioning. Through his published research, he explores the intricate connections between neuro-physiological development and functional visual performance, contributing valuable insights into therapeutic interventions. His 2024 study in the Journal of Eye Movement Research highlights asymmetries in fixation linked to primitive reflexes, while his 2022 and 2023 publications in Optometry & Visual Performance and Archives of Medical Science – Civilization Diseases further detail the association between reflex inhibition and visual system maturation. His unique integration of clinical practice and research allows him to continuously refine his Primitive Reflex Integration Therapy DM Primary Reflexes methodology, advancing the field by bridging the gap between theoretical neuroscience and practical therapeutic applications.

🔬 Research Focus

While Vicente A. Domingo-Sanz’s curriculum does not list formal awards, his significant professional achievements highlight his contributions to the field. The creation of Primitive Reflex Integration Therapy DM Primary Reflexes is a pioneering accomplishment, establishing him as a thought leader in reflex integration therapy. His research has been recognized through publication in respected peer-reviewed journals, including Journal of Eye Movement Research, Optometry & Visual Performance, and Archives of Medical Science – Civilization Diseases. These publications underscore the scientific community’s recognition of his expertise in the interaction between primitive reflexes and visual and motor functions. Additionally, his advanced certifications from international institutions such as INPP, BRMT, and the Svetlana Masgutova Institute demonstrate professional acknowledgment of his specialized skills and knowledge. His continuous education and contributions position him as a respected expert in motor therapy and neuroscience-based reflex integration, indirectly reflecting the professional esteem he holds among colleagues and the broader scientific community.

✅ Conclusion

Vicente A. Domingo-Sanz is a leading motor therapist who integrates advanced research and clinical expertise to address primitive reflex persistence, contributing significantly to neurodevelopmental therapy and advancing scientific understanding of the interplay between motor reflexes and visual function.

Publications

  • Persistence of primitive reflexes associated with asymmetries in fixation and ocular motility values

    Journal of Eye Movement Research
    2024-08-19 | Journal article
    DOI: 10.16910/jemr.17.2.5
    CONTRIBUTORS: Vicente A. Domingo-Sanz

  • Primitive reflexes beyond neonatal paediatrics: primitive reflexes and the visual system

    Archives of Medical Science – Civilization Diseases
    2023-09-30 | Journal article
    DOI: 10.5114/amscd.2023.131891
    CONTRIBUTORS: Vicente A. Domingo-Sanz

  • Inhibition of Primitive Reflexes and Its Relationship with Visual Projection in Children and Adolescents

    2022-12-24 | Journal article | Investigation
    CONTRIBUTORS: Vicente A. Domingo-San

Chan-Uk Yeom | Artificial Intelligence | Best Researcher Award

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Dr. Chan-Uk Yeom | Artificial Intelligence | Best Researcher Award

Dr. Chan-Uk Yeom is a Research Professor at the Research Institute of IT, Chosun University, Korea. He specializes in time series data analysis using deep learning, granular computing, adaptive neuro-fuzzy inference systems, high-dimensional data clustering, and biosignal-based biometrics. Dr. Yeom has held several research positions, including at the Division of AI Convergence College at Chosun University and the Center of IT-BioConvergence System Agriculture at Chonnam National University. His work integrates artificial intelligence, fuzzy systems, and granular models for practical applications such as healthcare, biometrics, and energy efficiency. Dr. Yeom has published extensively in high-impact journals and conferences, holds multiple patents, and has received numerous awards for his innovative research contributions. He actively teaches courses related to AI healthcare applications and electronic engineering. His collaboration and problem-solving skills have been demonstrated through his involvement in competitive AI research challenges and global innovation camps.

Professional Profile

Education

Dr. Yeom completed his entire higher education at Chosun University, Korea. He earned his Ph.D. in Engineering (2022) from the Department of Control and Instrumentation Engineering, with a dissertation on fuzzy-based granular model design using hierarchical structures under the supervision of Prof. Keun-Chang Kwak. Prior to this, he obtained his M.S. in Engineering (2017), focusing on ELM predictors using TSK fuzzy rules and random clustering, and his B.S. in Engineering (2016) in Control and Instrumentation Robotics. His academic work laid a strong foundation in machine learning, granular computing, and fuzzy inference systems, which became the core of his future research trajectory. Throughout his education, Dr. Yeom demonstrated academic excellence, leading to multiple thesis awards, and developed expertise in AI-driven applications for healthcare, energy optimization, and biometrics.

Experience

Currently, Dr. Yeom serves as a Research Professor at the Research Institute of IT, Chosun University (since January 2025). Previously, he was a Research Professor at Chosun University’s Division of AI Convergence College (2023–2024) and a Postdoctoral Researcher at the Center of IT-BioConvergence System Agriculture, Chonnam National University (2022–2023). His extensive research spans user authentication technologies using multi-biosignals, brain-body interface development using AI multi-sensing, and optimization of solar-based thermal storage systems. In addition to research, Dr. Yeom has contributed to teaching undergraduate courses, including AI healthcare applications, electronic experiments, capstone design, and open-source software. He is also experienced in mentorship, student internships, and providing special employment lectures. His active participation in national and international research projects and conferences reflects his global engagement and multidisciplinary expertise in artificial intelligence, healthcare, biometrics, and advanced fuzzy models.

Research Interests

Dr. Yeom’s research integrates deep learning, granular computing, and adaptive neuro-fuzzy systems to solve complex problems in healthcare, biometrics, energy efficiency, and time series data analysis. His innovative work focuses on designing hierarchical fuzzy granular models, developing incremental granular models with particle swarm optimization, and applying AI-driven methods to biosignal-based biometric authentication. Dr. Yeom has developed cutting-edge models for predicting energy efficiency, vehicle fuel consumption, water purification processes, and disease classification from ECG signals. His contributions also extend to explainable AI, emotion recognition, and non-contact biosignal acquisition using 3D-CNN. In addition to academic publications, he has secured multiple patents related to ECG-based personal identification methods, intelligent prediction systems, and granular neural networks. His interdisciplinary approach combines theoretical modeling, real-world applications, and collaborative AI system design, advancing the fields of biomedical informatics, neuro-fuzzy computing, and healthcare convergence technologies.

Awards

Dr. Yeom has received numerous awards recognizing his academic excellence. He earned multiple Excellent Thesis Awards from prestigious conferences, including the International Conference on Next Generation Computing (ICNGC 2024), the Korea Institute of Information Technology (KIIT Autumn Conference 2024), and the Annual Conference of Korea Information Processing Society (ACK 2024). His doctoral work was recognized at Chosun University’s 2021 Graduate School Doctoral Degree Award Ceremony. He also received the Outstanding Presentation Paper Award at the 2020 Korean Smart Media Society Spring Conference and the Excellent Thesis Award at the Korea Information Processing Society 2018 Spring Conference. Earlier, his problem-solving capabilities were showcased as a finalist and top 9 team at the 2018 AI R&D Challenge and during participation in the 2016 Global Entrepreneurship Korea Camp. These honors highlight his sustained contributions to AI research, innovation, and applied technological development.

Conclusion

Dr. Chan-Uk Yeom is a dynamic researcher whose pioneering contributions to granular computing, neuro-fuzzy systems, and AI healthcare applications demonstrate his exceptional expertise, innovative thinking, and global scientific impact, making him a valuable contributor to the advancement of next-generation intelligent systems.

 Publications

  • A Design of CGK-Based Granular Model Using Hierarchical Structure

    Applied Sciences
    2022-03 | Journal article | Author
    DOI: 10.3390/app12063154
    CONTRIBUTORS: Chan-Uk Yeom; Keun-Chang Kwak

  • Adaptive Neuro-Fuzzy Inference System Predictor with an Incremental Tree Structure Based on a Context-Based Fuzzy Clustering Approach

    Applied Sciences
    2020-11 | Journal article | Author
    DOI: 10.3390/app10238495
    CONTRIBUTORS: Chan-Uk Yeom; Keun-Chang Kwak

Lama AlKahlan | Dentistry – Finite element analysis | Innovative Research Award

Posted on by Cognitive Scientist Awards

Dr. Lama AlKahlan | Dentistry – Finite element analysis | Innovative Research Award

Lama Ahmed Alkahlan is a dedicated PhD candidate in Orthodontics at King Saud University, Riyadh, Saudi Arabia. With a passion for advancing orthodontic care, she combines clinical expertise with innovative research to improve patient outcomes. Earning her Bachelor’s degree in General Dentistry with Excellence and First-Class Honors from King Saud University (2013-2019), Lama has consistently demonstrated academic excellence. She holds two U.S. patents for innovative dental devices and has published impactful research on orthodontic biomechanics and oral health-related quality of life. Her active participation in national and international conferences, including the Saudi Orthodontics Society Conference, AEEDC, and SIDC, reflects her commitment to lifelong learning and contribution to the global orthodontic community. In addition to her research, Lama serves as an invited speaker and actively engages in scientific exhibitions and hackathons, showcasing her leadership and vision for advancing dental sciences.

Professional Profile

Education

Lama Ahmed Alkahlan pursued her academic journey entirely at King Saud University, Riyadh. She earned her Bachelor Degree of General Dentistry (BDS) from 2013 to 2019, graduating with Excellence and First-Class Honors, showcasing her dedication to academic rigor and clinical proficiency. Building on this foundation, she embarked on a Doctorate of Science in Dentistry (DScD) in Orthodontics, which she is expected to complete between 2020 and 2025. Her education reflects a comprehensive blend of theoretical knowledge, clinical practice, and research innovation, aligning with global standards in orthodontics. Throughout her academic career, she has participated in specialized training, workshops, and seminars that enhance her clinical expertise and research capabilities, preparing her for a career at the forefront of orthodontic science. Her commitment to continuous education is further evidenced by her numerous contributions to scientific conferences and exhibitions.

Experience

Lama Ahmed Alkahlan’s professional experience is rooted in academic excellence, clinical practice, and research innovation. As a PhD candidate at the Department of Pediatric Dentistry and Orthodontics, King Saud University, she engages in advanced orthodontic clinical care while simultaneously conducting cutting-edge research. Her clinical practice is complemented by participation in various scientific conferences such as the Saudi Orthodontics Society Conference, AEEDC, and SIDC, where she both contributes knowledge and stays updated on global advancements. Lama has also actively participated in prominent exhibitions and hackathons, including the Saudi Hackathon for Health and MIT Saudi Hackathon for Health, reflecting her interdisciplinary approach and interest in healthcare innovation. Her invited speaker roles and contributions to university exhibitions underline her ability to translate complex scientific ideas to broader audiences, enhancing community engagement and educational outreach.

Research Interests

Lama Ahmed Alkahlan’s research focuses on clinical orthodontics, biomechanical innovations, and improving patient care outcomes. Her work includes extensive iterative finite element analysis of molar uprighting, offering novel methods for estimating clinical treatment time—critical for improving treatment predictability and efficiency. She is particularly interested in the intersection of clinical practice and engineering solutions, as reflected in her patented inventions. Her studies also explore the psychosocial impact of malocclusion on oral health-related quality of life among Saudi orthodontic patients, contributing valuable insights to patient-centered care models. Lama’s research bridges the gap between advanced computational modeling and practical clinical applications, aiming to optimize orthodontic interventions. Her multi-disciplinary approach includes collaboration with engineers, clinicians, and researchers, ensuring that her findings have both scientific rigor and direct clinical relevance.

Awards

Lama Ahmed Alkahlan’s career is marked by prestigious awards and significant innovations. She received the esteemed title of “The Ideal Student” from King Saud University’s College of Dentistry in May 2019, recognizing her outstanding academic and extracurricular contributions. She holds two U.S. patents: the Magnetic Dental Education Model (US 10096267 B1, 2018) and the Uprighting Dental Appliance (US 12274598 B1, 2025), demonstrating her commitment to advancing dental technology. Her participation in numerous national and international conferences has earned her recognition as a rising leader in orthodontics. Additionally, her research publications in respected journals, such as Applied Sciences (MDPI) and Bioscience Biotechnology Research Communications, highlight her scientific contributions. Lama’s blend of academic excellence, innovation, and leadership underscores her role as a promising future leader in the field of orthodontics.

Conclusion

Lama Ahmed Alkahlan exemplifies a new generation of orthodontic leaders, blending clinical expertise, academic excellence, innovative research, and technological advancement to elevate patient care standards and contribute meaningfully to global orthodontic science.

 Publications

  • Extensive Iterative Finite Element Analysis of Molar Uprighting with the Introduction of a Novel Method for Estimating Clinical Treatment Time

    Applied Sciences
    2025-06 | Journal article | Author
    DOI: 10.3390/app15126463
    CONTRIBUTORS: Lama AlKahlan; Naif A. Bindayel; Abdelhafid MALLEK; Mohamed Bendjaballah

  • Impacts of Malocclusion on Oral Health-Related Quality Among Saudi Orthodontic Patients

    Bioscience Biotechnology Research Communications
    2021-09-25 | Journal article
    DOI: 10.21786/bbrc/14.3.48
    Part of ISSN: 0974-6455
    Part of ISSN: 2321-4007
    CONTRIBUTORS: Huda Alkawari

Jesus Avila | Tauopathies | Best Researcher Award

Posted on by Cognitive Scientist Awards

Prof. Jesus Avila | Tauopathies | Best Researcher Award

Dr. Jesus Avila is a distinguished cognitive scientist and Professor ad honorem at the Centro de Biologia Molecular Severo Ochoa (CBM-CSIC), Spain. He obtained his degree in Chemistry and PhD in Molecular Biology from Universidad Complutense Madrid, focusing on RNA polymerase in B. subtilis. His postdoctoral research at NIH, USA, centered on the SV40 virus. Throughout his prolific career, Dr. Avila has made groundbreaking contributions to understanding the neuronal cytoskeleton, particularly tau protein, its role in Alzheimer’s disease, and tauopathies. With over 694 published journal articles, 33 books, 4 patents, and collaborations across the USA, France, UK, Germany, and Spain, his work is internationally recognized. He serves on editorial boards of prestigious journals including EMBO J, FEBS Letters, Neuroscience, and Journal of Alzheimer’s Disease (Deputy Editor). Dr. Avila is a member of EMBO, Academia Europaea, AAAS, and Royal Academies of Sciences and Medicine of Spain.

Professional Profile

Education

Dr. Jesus Avila pursued his higher education at Universidad Complutense Madrid (UCM), earning a degree in Chemistry. He further specialized by completing a PhD in Molecular Biology at UCM, where his research focused on the B. subtilis RNA polymerase system. This solid foundation in molecular biology provided him with the expertise to investigate complex neurobiological mechanisms. He then advanced his academic career with postdoctoral training at the National Institutes of Health (NIH) in Bethesda, Maryland, USA, where he studied the SV40 virus—a crucial step that introduced him to advanced molecular virology and neurobiology techniques. This diverse academic background enabled him to establish a globally recognized research portfolio in neurodegeneration, particularly tau protein’s role in neuronal function and dysfunction.

Experience

Dr. Avila has an illustrious career spanning several decades at the Centro de Biologia Molecular Severo Ochoa (CBM-CSIC), where he has led pioneering research into the neuronal cytoskeleton, tau protein dysfunction, and neurodegenerative diseases. His early research at NIH on SV40 virus provided him with robust molecular expertise, which he translated into comprehensive studies on tauopathies and Alzheimer’s disease upon returning to Spain. Dr. Avila has successfully led over 30 major research projects, consulted on 8 industry collaborations, and published 694 peer-reviewed articles. His work includes the authorship of 33 books and the filing of 4 patents. Through sustained collaborations with global leaders in neuroscience from the USA, France, UK, Germany, and Spain, he has significantly advanced the understanding of aging and cognitive decline. His academic leadership and editorial roles underscore his vast experience in guiding both research and scientific discourse.

Research Interests

Dr. Avila’s research primarily investigates the neuronal cytoskeleton, with a central focus on tau protein and its role in neurodegeneration. Beginning with tau’s structural function in neurons, his work has expanded to explore how tau dysfunction contributes to Alzheimer’s disease and other tauopathies. Utilizing molecular and cellular approaches, including advanced mouse models, he has dissected the pathological mechanisms linking tau pathology to cognitive decline. Recognizing aging as the principal risk factor for Alzheimer’s disease, his current investigations target neuronal rejuvenation strategies to mitigate age-associated neurodegeneration. His integrative approach combines molecular biology, neurogenetics, and translational models, contributing significantly to the understanding of disease progression and potential therapeutic interventions. Through over 694 publications, 33 books, multiple patents, and international collaborations, Dr. Avila has substantially advanced the field of cognitive neuroscience, particularly in understanding and combating tau-mediated cognitive disorders.

Awards

Dr. Avila’s exemplary contributions have earned him numerous prestigious honors. He is an elected member of EMBO (European Molecular Biology Organization), Academia Europaea, AAAS (American Association for the Advancement of Science), and both the Royal Academies of Sciences and Medicine of Spain—testament to his global recognition and scientific excellence. His editorial appointments with highly respected journals such as EMBO J, FEBS Letters, Neuroscience, and his role as Deputy Editor of the Journal of Alzheimer’s Disease further validate his authority in cognitive and neurodegenerative research. His citation index surpasses 100 on Scopus, reflecting the significant influence of his work. His extensive collaborations with leading international research teams highlight his status as a respected leader in the global scientific community. The combination of his research excellence, mentorship, and leadership has positioned him as one of the foremost experts in cognitive science and neurobiology.

Conclusion

Dr. Jesus Avila’s distinguished career combines pioneering research on tau protein and Alzheimer’s disease, extensive international collaborations, over 694 publications, leadership roles in major journals, multiple prestigious memberships, and an unwavering focus on neuronal rejuvenation strategies, positioning him as a world-leading cognitive scientist whose work continues to advance global understanding of neurodegeneration.

 Publications

  • Protein tau phosphorylation in the proline rich region and its implication in the progression of Alzheimer’s disease

    Experimental Neurology
    2025 | Journal article
    DOI: 10.1016/j.expneurol.2024.115049

    EID:

    2-s2.0-85208758184

    Part ofISSN: 10902430 00144886
    CONTRIBUTORS: Merino-Serrais, P.; Soria, J.M.; Arrabal, C.A.; Ortigado-López, A.; Esparza, M.Á.G.; Muñoz, A.; Hernández, F.; Ávila, J.; DeFelipe, J.; León-Espinosa, G.

  • Retrotransposon Protein L1 ORF1p Expression in Aging Central Nervous System

    International Journal of Molecular Sciences
    2025-05-04 | Journal article
    DOI: 10.3390/ijms26094368
    CONTRIBUTORS: Laura Vallés-Saiz; Aaron Abdelkader-Guillén; Jesús Ávila; Félix Hernández

  • Shapeshifter W-Tau Peptide Inhibits Tau Aggregation and Disintegrates Paired Helical Filaments

    Biochemistry
    2025-04-15 | Journal article
    DOI: 10.1021/acs.biochem.4c00809
    CONTRIBUTORS: Indalo Domene-Serrano; Raquel Cuadros; Vega García-Escudero; Francisco Vallejo-Bedia; Ismael Santa-María; Laura Vallés-Saiz; Félix Hernandez; Jesús Avila

  • Peptide Family Promotes Brain Cell Rejuvenation and Improved Cognition through Peripheral Delivery

    ACS Omega
    2025-04-08 | Journal article
    DOI: 10.1021/acsomega.4c10849
    CONTRIBUTORS: Alejandro Anton-Fernandez; Indalo Domene-Serrano; Raquel Cuadros; Rocio Peinado-Cahuchola; Margarita Sanchez-Pece; Felix Hernandez; Jesus Avila

  • Partial reprogramming by cyclical overexpression of Yamanaka factors improves pathological phenotypes of tauopathy mouse model of human Alzheimer\’s disease

    Progress In Neurobiology
    2025-04-01 | Journal article | Author
    DOI: 10.1016/j.pneurobio.2025.102743

    SOURCE-WORK-ID:

    CSIC-GB950859

    EID:

    2-s2.0-85219079150

    Part ofISSN: 0301-0082
    CONTRIBUTORS: Alejandro Anton-Fernandez; Ruiz de Alegría, Álvaro; Mariscal-Casero, Ana; Roldán-Lázaro, Marta; Peinado-Cauchola, Rocío; Jesus Avila; Felix Hernandez

  • Hippocampal rejuvenation by a single intracerebral injection of one‐carbon metabolites in C57BL6 old wild‐type mice

    Aging Cell
    2025-01 | Journal article
    DOI: 10.1111/acel.14365
    CONTRIBUTORS: Alejandro Antón‐Fernández; Rocío Peinado Cauchola; Félix Hernández; Jesús Ávila

  • Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3

    eBioMedicine
    2024 | Journal article
    DOI: 10.1016/j.ebiom.2023.104953

    EID:

    2-s2.0-85181837483

    Part ofISSN: 23523964
    CONTRIBUTORS: Ruiz-Gabarre, D.; Vallés-Saiz, L.; Carnero-Espejo, A.; Ferrer, I.; Hernández, F.; Garcia-Escudero, R.; Ávila, J.; García-Escudero, V.

  • Involvement of the cellular prion protein in seeding and spreading of sarkosyl-derived fractions of Alzheimer´s disease in Prnp mutant mice and in the P301S transgenic tauopathy mice model

    bioRxiv
    2024 | Other
    DOI: 10.1101/2024.01.20.576414

    EID:

    2-s2.0-85184321414

    Part of ISSN: 26928205
    CONTRIBUTORS: Sala-Jarque, J.; Gil, V.; Andrés-Benito, P.; Lidón, L.; Yanac-Huertas, R.E.; López-León, C.F.; Hernández, F.; Ávila, J.; Lanciego, J.L.; Soriano, J. et al.

Xavier Altafaj | Cognitive Development | Best Researcher Award

Posted on by Cognitive Scientist Awards

Assist. Prof. Dr. Xavier Altafaj | Cognitive Development | Best Researcher Award

University of Barcelona, Spain

Xavier Altafaj, PhD (b. Nov 16, 1974, Barcelona , is a neuroscientist and biomedical researcher with deep expertise in glutamatergic neurotransmission . A committed leader in translational research, he currently serves as Principal Investigator of the “Glutamatergic Receptors in Health and Disease” team and Lecturer under the Serra Húnter program at the University of Barcelona . With over two decades of international research spanning France , Belgium , and Spain, Dr. Altafaj has contributed to understanding synaptic function and pathologies in neurodevelopmental and neurodegenerative disorders . He is an active voice in European neuroscience, having collaborated in multiple EU networks and initiatives. His impactful work includes advancing treatments for rare pediatric diseases and conditions like GRIN-related encephalopathies and autism spectrum disorders . Through his scientific leadership and public engagement, he bridges basic research with clinical applications and patient advocacy, reflecting a career marked by innovation, mentorship, and societal relevance .

Profile

Scopus

Scholar

🎓Education 

Dr. Altafaj holds a PhD in Biological Sciences from the University of Barcelona (2002) , where he previously earned his B.Sc. in Biological Sciences (1997) alongside another B.Sc. from Université Libre de Bruxelles . His academic training reflects a strong international dimension, including early specialization in developmental genetics during an Erasmus fellowship in Belgium (1996–97) . His doctoral research at the Department of Molecular Genetics (IRO, Barcelona) involved collaborations with prominent institutions including the Cajal Institute in Madrid and ESPCI in Paris, combining molecular biology, pharmacology, and physiology . Supported by multiple European fellowships , his education laid the groundwork for his lifelong interest in synaptic signaling and ion channel pathophysiology. Dr. Altafaj’s cross-border scientific foundation shaped his capacity to lead innovative research that addresses complex neurobiological questions, from genetic mechanisms to therapeutic approaches for brain disorders , setting the stage for his later roles in translational neuroscience research and teaching .

🧪Professional Experience 

Dr. Altafaj is currently Principal Investigator (since 2011) and Serra Húnter Lecturer (since 2020) at the University of Barcelona’s Faculty of Medicine . From 2011–2020, he led the “Glutamatergic Receptors in Health and Disease” group at IDIBELL as a “Miguel Servet” Researcher . Prior to that, he was Principal Investigator (2008–2010) and Postdoc (2007) at CRG’s Gene Therapy team in Barcelona . His early postdoctoral research (2002–2006) took place in France at Inserm U-607/CEA-Grenoble, investigating calcium channel pathologies . As a PhD student (1997–2002), he trained in molecular genetics in Barcelona with various national and international collaborations. His research has spanned gene therapy, neurodevelopment, and synaptic disorders. Across academic and clinical research centers, Dr. Altafaj has consistently focused on molecular neurobiology and translational science. He’s an active member of European networks and regularly mentors graduate students, making him a pillar in biomedical research and education across Europe .

🏅 Awards & Honors 

Dr. Altafaj has earned prestigious competitive funding and honors across Europe, including multiple tenured “Miguel Servet” investigator positions (2008–2017) , and awards from Down Syndrome foundations for innovative gene therapy work . His projects have attracted major grants from institutions like the Instituto de Salud Carlos III, La Marató TV3, and European ERA-NET NEURON, totaling over €1.5 million in funding . He received early recognition with the Alfred Jost Award (2004, Serono)  and held numerous postdoctoral fellowships (Beatriu de Pinós, AFM, EU CORDIS) . Recent accolades include charity-funded studies for GRIN disorder stratification (GRI-Italia, Grinpatías), and collaborative grants on autism and rare encephalopathies . His leadership in research networks (MINECO, AGAUR) and role as PI in over 20 funded projects showcase his impact in translational neuroscience. These distinctions highlight his success in bridging clinical needs with basic research and improving therapeutic strategies for neurogenetic disorders .

🔬 Research Focus 

Dr. Altafaj’s research explores glutamatergic receptors (particularly NMDA) in health and disease, with an emphasis on synaptopathies, neurodevelopmental disorders, and rare encephalopathies such as GRIN-related syndromes . His lab investigates how mutations in genes like GRIN2B and CNTNAP2 disrupt synaptic signaling and contribute to conditions like autism, epilepsy, and intellectual disability . Using patient-derived models, proteomics, and pharmacological tools, his group develops personalized medicine strategies and functional stratification of variants . Ongoing work includes translational studies on l-serine and spermidine treatments, contributing to experimental therapies for pediatric patients . He also delves into the interaction between glutamate receptors and neuroinflammatory pathways, relevant in diseases like Alzheimer’s . His multidisciplinary approach merges genetics, molecular biology, and neuropharmacology, often in collaboration with clinicians and European consortia . Dr. Altafaj aims to bridge molecular mechanisms with clinical interventions, advancing therapeutic innovation and patient-centered research in neurology and psychiatry .

✅ Conclusion: 

Dr. Xavier Altafaj is a highly suitable candidate for a Best Researcher Award, especially in fields like translational neuroscience, molecular neurogenetics, or rare disease research. His long-term leadership, groundbreaking work on glutamatergic signaling, and consistent research funding validate his excellence in academia and applied health sciences. While there is room to amplify his global visibility and innovation footprint, his current record already reflects the high standards expected of award recipients.

Publication

  • Title: Neurodevelopmental delay, motor abnormalities, and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down’s syndrome
    Authors: X. Altafaj, M. Dierssen, C. Baamonde, E. Martí, J. Visa, J. Guimerà, M. Oset, et al.
    Year: 2001
    Citations: 503

  • Title: Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system
    Authors: E. Martí, X. Altafaj, M. Dierssen, S. de la Luna, V. Fotaki, M. Alvarez, et al.
    Year: 2003
    Citations: 174

  • Title: Interaction between the dihydropyridine receptor Ca2+ channel β-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling
    Authors: W. Cheng, X. Altafaj, M. Ronjat, R. Coronado
    Year: 2005
    Citations: 119

  • Title: DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding
    Authors: M. Alvarez, X. Altafaj, S. Aranda, S. de la Luna
    Year: 2007
    Citations: 107

  • Title: Transduction of the scorpion toxin maurocalcine into cells: evidence that the toxin crosses the plasma membrane
    Authors: E. Estève, K. Mabrouk, A. Dupuis, S. Smida-Rezgui, X. Altafaj, D. Grunwald, et al.
    Year: 2005
    Citations: 103

  • Title: Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction
    Authors: M. M. de Lagrán, X. Altafaj, X. Gallego, E. Martí, X. Estivill, I. Sahún, C. Fillat, et al.
    Year: 2004
    Citations: 102

  • Title: Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases
    Authors: S. Leder, Y. Weber, X. Altafaj, X. Estivill, H. G. Joost, W. Becker
    Year: 1999
    Citations: 97

  • Title: Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome
    Authors: X. Altafaj, E. D. Martín, J. Ortiz-Abalia, A. Valderrama, C. Lao-Peregrín, et al.
    Year: 2013
    Citations: 96

  • Title: Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome
    Authors: J. Ortiz-Abalia, I. Sahún, X. Altafaj, N. Andreu, X. Estivill, M. Dierssen, C. Fillat
    Year: 2008
    Citations: 91

  • Title: Glutamate receptor mutations in psychiatric and neurodevelopmental disorders
    Authors: D. Soto, X. Altafaj, C. Sindreu, À. Bayés
    Year: 2014
    Citations: 89